VERFAHREN ZUR HERSTELLUNG VON CHIRALEN IMIDAZOLIDIN-2-ONEN
    2.
    发明授权
    VERFAHREN ZUR HERSTELLUNG VON CHIRALEN IMIDAZOLIDIN-2-ONEN 有权
    用于生产手性咪唑啉-2-酮

    公开(公告)号:EP1497267B1

    公开(公告)日:2008-10-15

    申请号:EP03722413.6

    申请日:2003-04-08

    Applicant: BASF SE

    CPC classification number: C07D233/00

    Abstract: The invention relates to a method for producing chiral imidazolidin-2-ones of general formula (I), in which R1 represents C1-C8-alkyl, cyclohexyl-, phenyl-, a phenyl radical substituted with C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy-, C1-C6-alkylmercapto-, or CF3-, naphthyl-, or a naphthyl radical substituted with C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy-, or CF3-, R2 represents C1-C8-alkyl-, C1-C8-alkenyl, cyclohexyl-, phenyl-, or a phenyl-C1-C6-alkyl radical which can be substituted with a nitro-, C1-C6-alkoxy-, methylendioxi-, or CF3 radical, and R3 represents C1-C12 alkyl-, C1-C8-alkenyl-, cyclohexyl-, phenyl-, or a phenyl radical substituted with C1-C6-alkyl-, halo-, nitro-, C1-C6-alkoxy, methylendioxi-, dialkylamine-, or CF3-, by reacting a compound of general formula II or the salt thereof, R1, R2, and R3 having the meaning indicated above, with urea in the presence of a non-volatile ammonium salt, said reaction being carried out in the presence of an aprotic polar organic solvent.

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