公开(公告)号：EP2542257A4

公开(公告)日：2013-11-13

申请号：EP11751244

申请日：2011-03-01

申请人： BAYER HEALTHCARE LLC

发明人： SCHOLZ PETER ,  WANG ZHUOZHI ,  PAN JUNLIANG ,  GRUDZINSKA JOANNA ,  VOTSMEIER CHRISTIAN ,  TEBBE JAN ,  BIRKENFELD JOERG ,  WOBST NINA ,  BRUECKNER SIMONE ,  STEINIG SUSANNE

IPC分类号： C07K16/38 ,  A61K39/00 ,  A61K39/395

CPC分类号： C07K16/38 ,  A61K2039/505 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/21

摘要： Isolated monoclonal antibodies that bind human tissue factor pathway inhibitor (TFPI) are provided. Isolated nucleic acid molecules encoding monoclonal antibodies that bind TFPI are also contemplated. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided. Methods of producing the antibodies are also provided.