公开(公告)号：EP1781338A4

公开(公告)日：2010-02-10

申请号：EP05857799

申请日：2005-06-23

申请人： BAYLOR COLLEGE MEDICINE

发明人： CHEN SI-YI ,  SHEN LEI ,  EVEL-KABLER KEVIN C ,  HUANG XUE F

IPC分类号： C07H21/04 ,  A61K48/00 ,  C12N5/0784 ,  C12N15/113

CPC分类号： C12N5/0639 ,  A61K9/0019 ,  A61K9/127 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/53 ,  A61K2039/55516 ,  A61K2039/55522 ,  C07K14/005 ,  C12N15/113 ,  C12N2310/14 ,  C12N2510/00 ,  C12N2710/10343 ,  C12N2740/15043 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2830/60

摘要： The present invention relates to regulation of antigen presentation by cytokine signaling regulators in antigen presenting cells, such as dendritic cells. The invention provides methods of modulating antigen presentation through modulation of cytokine signaling regulators, such as SOCS (SOCS1-7, CIS), SHP (SHP-1 and SHP-2) or PIAS (PIAS1, PIAS3, PIASx and PIASy). The present invention provides vaccines and therapies in which antigen presentation is enhanced through modulation of cytokine signaling regulators. The present invention also provides a mechanism to break self tolerance in tumor vaccination methods that rely on presentation of self tumor antigens.

公开(公告)号：EP1917038A4

公开(公告)日：2010-01-13

申请号：EP06718772

申请日：2006-01-19

申请人： BAYLOR COLLEGE MEDICINE

发明人： CHEN SI-YI ,  EVEL-KABLER KEVIN C ,  SONG XIAOTONG ,  HUANG XUE F ,  SHARABI ANDREW

IPC分类号： C07H21/04

CPC分类号： C12N5/0639 ,  C12N15/113 ,  C12N2310/14 ,  C12N2501/60