利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

2 条记录 (耗时 0.01 秒)

    METHOD FOR SYNTHESIZING THYMOSINS
    1.
    发明公开
    METHOD FOR SYNTHESIZING THYMOSINS 有权
    VERFAHREN ZUR SYNTHETISIERUNG VON THYMOSINEN

    公开(公告)号：EP2019118A1

    公开(公告)日：2009-01-28

    申请号：EP07765833.4

    申请日：2007-04-25

    申请人： BCN Peptides, S.A.

    发明人： FERNANDEZ CARNEADO, Jimena ,  PONSATI OBIOLS, Berta ,  CLEMENTE RODRIGUEZ, Javier ,  RUBIRES FERRER, Raimon ,  PAVON FERNANDEZ, Sergi

    IPC分类号： C07K14/575 ,  C07K17/08 ,  A61K38/22 ,  A61P29/00 ,  A61P35/00

    CPC分类号： C07K1/065 ,  A61K38/00 ,  C07K14/57581

    摘要： The invention relates to a method for obtaining thymosins and/or the pharmaceutically acceptable salts thereof by means of solid-phase synthesis on polymeric supports, which comprises the steps of linearly synthesizing the thymus-derived peptides in solid phase, incorporating at least one Thr or Ser in the sequence, in pseudoproline dipeptide form, obtaining the thymosins by treating the peptidyl resin with trifluoroacetic acid, and purifying the thymosins by RP-HPLC. The present invention also protects the isolated and/or purified compound obtained by means of said method and also the use thereof in the preparation of a medicinal product.

    摘要翻译： 本发明涉及通过固相合成在聚合物载体上获得胸腺素和/或其药学上可接受的盐的方法，该方法包括以下步骤：在固相中线性合成来自胸腺的肽，并入至少一种Thr或 以脯氨酸二肽形式顺序序列，通过用三氟乙酸处理肽基树脂获得胸腺素，并通过RP-HPLC纯化胸腺素。 本发明还保护通过所述方法获得的分离和/或纯化的化合物以及其在制备药物中的用途。