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公开(公告)号：EP0568160B1
公开(公告)日：1997-06-11
申请号：EP93202062.1
申请日：1989-10-11
申请人： BEECHAM GROUP PLC
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公开(公告)号：EP0568160A3
公开(公告)日：1994-01-12
申请号：EP93202062.1
申请日：1989-10-11
申请人： BEECHAM GROUP PLC
发明人： Alexander, Stephen Edward SmithKline Beecham , Doel, Geoffrey Royston SmithKline Beecham , Edward, Peter John SmithKline Beecham
摘要： The problem of formulating a dentifrice which is compatible with a bis-biguanide anti-bacterial agent, for instance chlorhexidine or alexidine, is solved by using a nonionic thickening agent; a nonionic surfactant; and an abrasive which is either a sparingly soluble salt, for instance calcium carbonate, (used in combination with an agent to suppress anion formation), or an essentially insoluble compound, for instance, a silica of low anion content, or a mixture thereof. Preferably, the composition has a flavour which is mainly aniseed, balanced by mints. Preferably during the preparation of a silica containing dentifrice, chlorhexidine and saccharin are added together at an early stage, prior to the addition of silica, to avoid the formation of lumps. Such dentifrices are useful in the prophylaxis and/or treatment of periodontal disease and caries.
摘要翻译： 通过使用非离子增稠剂来解决配制与双胍类抗菌剂例如氯己定或阿来西定相容的洁牙剂的问题; 非离子表面活性剂; 和微溶盐（例如碳酸钙）（与抑制阴离子形成的试剂组合使用）或基本上不溶的化合物（例如低阴离子含量的二氧化硅）或其混合物的磨料。 优选地，该组合物具有主要被大茴香，薄荷糖平衡的风味。 优选在制备含二氧化硅的洁牙剂期间，在加入二氧化硅之前，在早期阶段将氯己定和糖精一起加入，以避免形成团块。 这种洁牙剂可用于预防和/或治疗牙周病和龋齿。
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公开(公告)号：EP0568160A2
公开(公告)日：1993-11-03
申请号：EP93202062.1
申请日：1989-10-11
申请人： BEECHAM GROUP PLC
发明人： Alexander, Stephen Edward SmithKline Beecham , Doel, Geoffrey Royston SmithKline Beecham , Edward, Peter John SmithKline Beecham
摘要： The problem of formulating a dentifrice which is compatible with a bis-biguanide anti-bacterial agent, for instance chlorhexidine or alexidine, is solved by using a nonionic thickening agent; a nonionic surfactant; and an abrasive which is either a sparingly soluble salt, for instance calcium carbonate, (used in combination with an agent to suppress anion formation), or an essentially insoluble compound, for instance, a silica of low anion content, or a mixture thereof. Preferably, the composition has a flavour which is mainly aniseed, balanced by mints. Preferably during the preparation of a silica containing dentifrice, chlorhexidine and saccharin are added together at an early stage, prior to the addition of silica, to avoid the formation of lumps. Such dentifrices are useful in the prophylaxis and/or treatment of periodontal disease and caries.
摘要翻译： 通过使用非离子增稠剂来解决配制与双双胍类抗菌剂（例如洗必太或吖啶啶）相容的洁齿剂的问题; 非离子表面活性剂; 和作为微溶盐的研磨剂，例如碳酸钙，（与药剂组合以抑制阴离子形成），或基本上不溶的化合物，例如低阴离子含量的二氧化硅或其混合物。 优选地，组合物具有主要是茴香的风味，通过薄荷平衡。 优选在制备含二氧化硅的洁齿剂期间，在添加二氧化硅之前的早期阶段将氯己定和糖精加入到一起，以避免形成块状物。 这种牙粉可用于预防和/或治疗牙周病和龋齿。
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