公开(公告)号：EP1545585A1

公开(公告)日：2005-06-29

申请号：EP03794046.7

申请日：2003-09-08

申请人： BEN-GURION UNIVERSITY OF THE NEGEV

发明人： SEKLER, Israel ,  HERSHFINKEL, Michal ,  SILVERMAN, Ze'ev ,  MORAN, Arie

IPC分类号： A61K38/17 ,  A61P9/10 ,  A61P9/12

CPC分类号： A61K38/1709

摘要： The present invention relates to the use of ZnT-1, originally described as a zinc transporter, in the regulation of L-type calcium channels (LTCC). In this study, the inventors have unexpectedly demonstrated that ZnT-1 physically interacts with LTCC, regulating its function. Most importantly, the inventors have shown that ZnT-1 can regulate intracellular Ca2+ influx, and thus, its intracellular concentration. This is the first demonstration of a natural blocker for LTCC, and it is a promising breakthrough as a potential agent to be used in the treatment and/or prevention of cardiovascular diseases and related indications.