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9 条记录 (耗时 0.009 秒)

    PURIFICATION PROCESS
    1.
    发明公开
    PURIFICATION PROCESS 失效

    公开(公告)号：EP0968214A1

    公开(公告)日：2000-01-05

    申请号：EP98907945.4

    申请日：1998-01-14

    申请人： BIOCHEMIE GESELLSCHAFT M.B.H.

    发明人： LUDESCHER, Johannes ,  MILLER, Ludwig ,  STURM, Hubert ,  VEIT, Werner ,  DECRISTOFORO, Martin ,  WOLF, Siegfried

    IPC分类号： C07D501/00 ,  C12P17/18

    CPC分类号： C07D501/00

    摘要： Crystalline 2-(aminothiazol-4-yl)-2-(tert.butoxycarbonylmethoxyimino)acetic acid-S-mercapto-benzo-thiazolylester in form of an N,N-dimethylacetamide solvate; a crystalline salt of a 7-[2-(aminothiazol-4-yl)-2-(carboxymethoxyimino)acetamido]-3-vinyl-3-cephem-4-carboxylic acid with an amine of formula N(R1)(R2)(R3), wherein R1, R2, and R3 have various meanings, a crystalline sulphuric acid addition salt of a 7-[2-(2-aminothiazol-4-yl)-2-carboxymethoxyimino)acetamido]-3-vinyl-3-cephem-4-carboxylic acid; and the use of these salts in the production of cefixime, e.g. in form of a trihydrate.

    CRYSTALLINE BETA-LACTAM INTERMEDIATE
    5.
    发明公开
    CRYSTALLINE BETA-LACTAM INTERMEDIATE 有权
    CRYSTALβ-内酰胺中间体

    公开(公告)号：EP1173444A1

    公开(公告)日：2002-01-23

    申请号：EP00943708.8

    申请日：2000-05-03

    申请人： BIOCHEMIE Gesellschaft m.b.H.

    发明人： GREIL, Julia ,  LUDESCHER, Johannes ,  TOTSCHNIG, Klaus ,  WOLF, Siegfried

    IPC分类号： C07D501/04 ,  C07D501/12 ,  C07D501/34

    CPC分类号： C07D501/00

    摘要： The novel intermediate compound crystalline 7-[2-(2-fomylaminothiazol-4-yl)-2 -(Z)-(methoxyimino)acetamido]-3-methoxymethyl-3-cephem-4-carboxylic acid-1 -(isopropoxy/crystallization of cefpodoxime proxetil. The crystallization process comprises dissolving or suspending the intermediate in the presence of a nitrile or a ketone or mixtures thereof; at a ratio of 1 gm of the intermediate to 2-15 ml nitrile; or at a ratio of 1 gm of the intermediate to 3-15 ml ketone; in the presence of 5-80 ml water; and thereafter isolating the intermediate in crystalline form and converting the intermediate by splitting off the formyl group from the amino group attached to the thiazolyl group, to obtain the desired product cefpodoxime proxetil, in the form of a diastereoisomeric mixture in a ratio of B/(A+B) of 0.5 to 0.6.

    PROCESS FOR THE PURIFICATION OF A 3-CEPHEM-4-CARBOXYLIC ACID DERIVATIVE
    7.
    发明公开
    PROCESS FOR THE PURIFICATION OF A 3-CEPHEM-4-CARBOXYLIC ACID DERIVATIVE 失效
    清理方法的3-头孢烯-4-羧酸衍生物。

    公开(公告)号：EP0630380A1

    公开(公告)日：1994-12-28

    申请号：EP93901714.0

    申请日：1992-12-21

    申请人： BIOCHEMIE GESELLSCHAFT M.B.H.

    发明人： LUDESCHER, Johannes ,  PRAGER, Bernhard ,  WOLF, Siegfried

    IPC分类号： C07D501

    CPC分类号： C07D501/00

    摘要： L'invention se rapporte à un nouveau procédé destiné à l'épuisement de l'acide 7-amino-3-[(E)-1-propen-1-yl]-3-céphem-4-carboxylique dans des mélanges d'acide 7-amino-3-[(Z)-1-propen-1-yl]-3-céphem-1-carboxylique et d'acide 7-amino-3-[(E)-1-propen-1-yl]-3-céphem-4-carboxylique, par l'intermédiaire de l'hydrochlorure cristallin ou d'un sel amine ou métallique d'acide 7-amino-3-[(Z/E)-1-propen-1-yl]-3-céphem-4-carboxylique, ou par chromatographie par absorption.

    PURIFICATION PROCESS
    8.
    发明授权
    PURIFICATION PROCESS 失效
    净化过程

    公开(公告)号：EP0968214B1

    公开(公告)日：2004-04-07

    申请号：EP98907945.4

    申请日：1998-01-14

    申请人： BIOCHEMIE GESELLSCHAFT M.B.H.

    发明人： LUDESCHER, Johannes ,  MILLER, Ludwig ,  STURM, Hubert ,  VEIT, Werner ,  DECRISTOFORO, Martin ,  WOLF, Siegfried

    IPC分类号： C07D501/00 ,  C12P17/18

    CPC分类号： C07D501/00

    摘要： Crystalline 2-(aminothiazol-4-yl)-2-(tert.butoxycarbonylmethoxyimino)acetic acid-S-mercapto-benzo-thiazolylester in form of an N,N-dimethylacetamide solvate; a crystalline salt of a 7-[2-(aminothiazol-4-yl)-2-(carboxymethoxyimino)acetamido]-3-vinyl-3-cephem-4-carboxylic acid with an amine of formula N(R1)(R2)(R3), wherein R1, R2, and R3 have various meanings, a crystalline sulphuric acid addition salt of a 7-[2-(2-aminothiazol-4-yl)-2-carboxymethoxyimino)acetamido]-3-vinyl-3-cephem-4-carboxylic acid; and the use of these salts in the production of cefixime, e.g. in form of a trihydrate.

    摘要翻译： N，N-二甲基乙酰胺溶剂化物形式的结晶2-（氨基噻唑-4-基）-2-（叔丁氧基羰基甲氧基亚氨基）乙酸-S-巯基 - 苯并噻唑基酯; 7-（2-（氨基噻唑-4-基）-2-（羧甲氧基亚氨基）乙酰胺基] -3-乙烯基-3-头孢烯-4-羧酸与式N（R 1）（R 2） （R3）（其中R1，R2和R3具有各种含义），7- [2-（2-氨基噻唑-4-基）-2-羧甲氧基亚氨基）乙酰氨基] -3-乙烯基-3 - 头孢烯-4-羧酸; 以及这些盐在头孢克肟生产中的用途，例如 以三水合物的形式。