公开(公告)号：EP0606463A1

公开(公告)日：1994-07-20

申请号：EP93918408.0

申请日：1993-07-27

申请人： The Administrators of The Tulane Educational Fund ,  BIOMEASURE INC.

发明人： COY, David, H. ,  TAYLOR, John, E.

IPC分类号： A61K38 ,  A61P43 ,  C07K7 ,  C07K14

CPC分类号： C07K14/6555 ,  A61K38/31

摘要： L'invention concerne des procédés d'inhibition sélective de l'activité biochimique de cellules induite par la neuromédine B. Ledit procédé consiste à mettre des cellules contenant le récepteur de la neuromédine B en contact avec un octapeptide cyclique, représenté par D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Nal-NH2, ou un analogue de celui-ci.

公开(公告)号：EP0606463B1

公开(公告)日：2001-10-04

申请号：EP93918408.1

申请日：1993-07-27

申请人： The Administrators of The Tulane Educational Fund ,  BIOMEASURE, INC.

发明人： COY, David, H. ,  TAYLOR, John, E.

IPC分类号： A61K38/08 ,  C07K7/06 ,  C07K14/655

CPC分类号： C07K14/6555 ,  A61K38/31

摘要： A method of selectively inhibiting biochemical activity of cells induced by neuromedin B. The method includes the step of contacting cells which contain neuromedin B receptor with a cyclic octapeptide, D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Nal-NH2, or an analog thereof.

公开(公告)号：EP0859785B1

公开(公告)日：2001-05-30

申请号：EP96929913.0

申请日：1996-09-04

申请人： BIOMEASURE, INC. ,  The Administrators of The Tulane Educational Fund

发明人： COY, David, H. ,  TAYLOR, John, E.

IPC分类号： C07K7/00 ,  C07K14/655

CPC分类号： C07K14/6555 ,  A61K38/00 ,  Y10S930/16

摘要： A cyclic peptide analog of somatostatin wherein a disulfide bond links the N-terminus residue and the C-terminus residue.

公开(公告)号：EP0859785A1

公开(公告)日：1998-08-26

申请号：EP96929913.0

申请日：1996-09-04

申请人： BIOMEASURE, INC. ,  The Administrators of The Tulane Educational Fund

发明人： COY, David, H. ,  TAYLOR, John, E.

IPC分类号： C07K ,  C07K7 ,  C07K14 ,  A61K38

CPC分类号： C07K14/6555 ,  A61K38/00 ,  Y10S930/16

摘要： A cyclic peptide analog of somatostatin wherein a disulfide bond links the N-terminus residue and the C-terminus residue.

公开(公告)号：EP1011716B9

公开(公告)日：2004-03-03

申请号：EP95943375.6

申请日：1995-12-07

申请人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND ,  SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S.

发明人： COY, David, H. ,  TAYLOR, John, E.

IPC分类号： A61K38/31 ,  C07K7/00 ,  C07K14/655

CPC分类号： A61K38/31 ,  C07K14/6555

公开(公告)号：EP0438519B1

公开(公告)日：1998-05-06

申请号：EP89912292.3

申请日：1989-10-13

申请人： The Administrators of The Tulane Educational Fund

发明人： COY, David, H. ,  MOREAU, Jacques-Pierre ,  TAYLOR, John, E. ,  KIM, Sun, Hyuk

IPC分类号： C07K7/02 ,  C07K14/595 ,  A61K38/16

CPC分类号： C07K14/57572 ,  A61K38/00 ,  C07K7/02 ,  C07K7/086

摘要： In general, the invention features a linear (i.e., non-cyclic) bombesin analog of biologically active mammalian gastrin-releasing peptide (GRP) and amphibian bombesin, having an active site and a binding site responsable for the binding of the peptide to a receptor on a target cell; cleavage of a peptide bond in the active site of naturally occuring bombesin or GRP is unnecessary for in vivo bilogical activity. The analog has one of the following modifications: (a) a deletion of a residue within the active site and a modification of a residue outside of the active site, or (b) a remplacement of one or two residues within the active site with a synthetic amino acid. The analog is capable of binding to the receptor and acting as a competitive inhibitor of the naturally occurring peptide by binding to the receptor and, by virtue of one of the modifications, failing to exhibit the in vivo biological activity of the naturally occurring peptide.

公开(公告)号：EP0344297A1

公开(公告)日：1989-12-06

申请号：EP89901170.0

申请日：1988-11-18

申请人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND

发明人： TAYLOR, John, E. ,  BOGDEN, Arthur, E. ,  MOREAU, Jacques-Pierre ,  COY, David, H.

IPC分类号： A61K38 ,  A61P35 ,  C07K14

CPC分类号： C07K14/6555 ,  A61K38/00

摘要： A method of treating a mammal suffering from cancer by administering to the mammal somatostatin or an analog thereof, the analog being a hexapeptide analog or higher, in a dosage of at least 25 µg/kg/day.

公开(公告)号：EP1355940B1

公开(公告)日：2007-10-03

申请号：EP01987763.8

申请日：2001-10-19

申请人： The Administrators of The Tulane Educational Fund ,  SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S.

发明人： COY, David, H. ,  ROSSOWSKI, Wojciech, J. ,  TAYLOR, John, E.

IPC分类号： C07K14/575 ,  A61K38/22

CPC分类号： C07K7/52 ,  A61K38/00 ,  C07K14/57509

摘要： The present invention features a novel class of cyclic polypeptides that have U-II antagonist and agonist activity. The invention also features methods for treating physiological or psychological conditions characterized by an excess or under expression of Ur4otensin-II.

公开(公告)号：EP1011716B1

公开(公告)日：2003-07-23

申请号：EP95943375.6

申请日：1995-12-07

申请人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND ,  SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A.S.

发明人： COY, David, H. ,  TAYLOR, John, E.

IPC分类号： A61K38/31 ,  C07K7/00 ,  C07K14/655

CPC分类号： A61K38/31 ,  C07K14/6555

公开(公告)号：EP0344297B1

公开(公告)日：1994-05-11

申请号：EP89901170.4

申请日：1988-11-18

申请人： The Administrators of The Tulane Educational Fund

发明人： TAYLOR, John, E. ,  BOGDEN, Arthur, E. ,  MOREAU, Jacques-Pierre ,  COY, David, H.

IPC分类号： A61K37/24

CPC分类号： C07K14/6555 ,  A61K38/00

摘要： A method of treating a mammal suffering from cancer by administering to the mammal somatostatin or an analog thereof, the analog being a hexapeptide analog or higher, in a dosage of at least 25 mug/kg/day.