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公开(公告)号:EP3250562A4
公开(公告)日:2018-07-11
申请号:EP16744240
申请日:2016-01-29
发明人: DECRESCENZO GARY , WELSCH DEAN , VLAHOVA PETINKA I , BOERRIGTER STEPHAN X M , ARONOV ALEXANDER , KESHAVARZ-SHOKRI ALI , SCANGAS ALEXANDER N , STAVROPOULOS KATHY , LITTLER BENJAMIN , KADIYALA IRINA NIKOLAEVNA , ALARGOVA ROSSITZA GUEORGUIEVA
IPC分类号: C07D401/04 , A61K31/4439 , A61K45/06 , A61P35/00
CPC分类号: C07D401/04 , A61K31/4439 , A61K45/06 , A61P35/00
摘要: The present invention provides crystalline forms of a compound of formula (I): Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.
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2.CANCER TREATMENT USING COMBINATIONS OF ERK AND RAF INHIBITORS 审中-公开
标题翻译: KREBSBEHANDLUNG MITTELS KOMBINATIONEN AUS ERK- UND RAF-HEMMERN公开(公告)号:EP3082800A4
公开(公告)日:2017-07-05
申请号:EP14872061
申请日:2014-12-19
IPC分类号: A61K31/519 , A61K31/4439 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/555 , A61K45/06 , A61P35/00
CPC分类号: A61K31/4439 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/555 , A61K45/06 , A61K2300/00
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3.CANCER TREATMENTS USING COMBINATIONS OF CDK AND ERK INHIBITORS 审中-公开
标题翻译: KREBSBEHANDLUNGEN UNTER VERWENDUNG VON KOMBINATIONEN AUS CDK- UND ERK-HEMMERN公开(公告)号:EP3082423A4
公开(公告)日:2017-09-20
申请号:EP14872163
申请日:2014-12-19
IPC分类号: A01N43/40 , A61K31/4439 , A61K31/505 , A61P35/00 , C07D401/00
CPC分类号: A61K31/519 , A61K31/4439 , A61K31/506 , A61K45/06 , C07D401/04 , A61K2300/00
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4.CANCER TREATMENTS USING COMBINATIONS OF PI3K/AKT PATHWAY AND ERK INHIBITORS 审中-公开
标题翻译: KREBSBEHANDLUNGEN UNTER VERWENDUNG VON KOMBINATIONEN AUS PI3K / AKT-SIGNALWEG- UND ERK-HEMMERN公开(公告)号:EP3082957A4
公开(公告)日:2017-06-21
申请号:EP14871139
申请日:2014-12-19
IPC分类号: A61P35/00 , A61K31/4439 , A61K31/5377 , A61K45/06
CPC分类号: A61K31/4439 , A61K31/506 , A61K31/5377 , A61K45/06 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , A61K2300/00
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公开(公告)号:EP3250291A4
公开(公告)日:2018-07-18
申请号:EP16744245
申请日:2016-01-29
IPC分类号: C07D401/04 , A61K31/4439 , A61K45/06 , A61P35/00 , C07C55/08
CPC分类号: C07D401/04 , A61K31/4439 , A61K45/06 , C07B2200/13 , C07C55/08
摘要: The present invention provides a malonate salt of a compound of formula (I): which is a crystalline salt. Also provided are pharmaceutical compositions that include the provided malonate salt and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.
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6.CANCER TREATMENTS USING COMBINATIONS OF TYPE 2 MEK AND ERK INHIBITORS 审中-公开
标题翻译: KREBSBEHANDLUNGEN UNTER VERWENDUNG VON KOMBINATIONEN AUS TYP-2-MEK- UND ERK-HEMMERN公开(公告)号:EP3082779A4
公开(公告)日:2017-07-05
申请号:EP14871217
申请日:2014-12-19
IPC分类号: A61K31/4439 , A61K31/337 , A61K31/437 , A61K31/506 , A61K31/519 , A61P35/00
CPC分类号: A61K31/4439 , A61K31/337 , A61K31/4184 , A61K31/437 , A61K31/506 , A61K31/519 , A61K45/06 , A61K2300/00
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7.CANCER TREATMENTS USING COMBINATIONS OF MEK TYPE I AND ERK INHIBITORS 审中-公开
标题翻译: KREBSBEHANDLUNGEN UNTER VERWENDUNG VON KOMBINATIONEN AUS TYP-1-MEK-UND -ERK-HEMMERN公开(公告)号:EP3082422A4
公开(公告)日:2017-07-05
申请号:EP14871339
申请日:2014-12-19
IPC分类号: A61K31/4439 , A61K31/365 , A61K31/5377 , A61P35/00
CPC分类号: A61K31/4439 , A61K31/365 , A61K31/5377 , A61K45/06 , A61K2300/00
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