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公开(公告)号：EP1578759A1
公开(公告)日：2005-09-28
申请号：EP03814482.0
申请日：2003-12-16
申请人： BIOMERIEUX SA
IPC分类号： C07H21/00
摘要： The invention relates to novel pyrrole derivatives of the formula (I) which make it possible to immobilise and address olionucleotides by electropolymerisation. Said invention also relates to thus produced electroactive polymers and to methods for using them for detecting, identifying and dosing analytes in a sample. (I) wherein, R1 is one type of oligonucleotide, Y is S or O, X is a spacer arm selected from -(CH2) -O-, -(CH2)P O-[(CH2)2-O] q-, -(CH2)r; -CO-NR'-(CH2 )r-0-, -(CH2 )r-NCH3-(CH2 )r-O-, -(CH2)r CO-NR'-[(CH2)2 -O]s-, -(CH2)r NCH3-[(CH2)2-O]S-, R' is H or CH3, n is an integer number ranging from 1 to 5, p is an integer number ranging from 1 to 2, q is an integer number ranging from 1 to 4, r is an integer number ranging from 1 to 3, r' is an integer number ranging from 1 to 3, s is an integer number ranging from 1 to 3, n, p, q, r, r' and s are identical or different, a pyrrole cycle is substituted in a position 2,3 4, or 5.
摘要翻译： 本发明涉及式（I）的新型吡咯衍生物，其可以通过电聚合固定和解决寡核苷酸。 本发明还涉及如此生产的电活性聚合物和使用它们检测，鉴定和定量样品中分析物的方法。 （I）其中，R 1是一种寡核苷酸，Y是S或O，X是选自 - （CH 2）-O-， - （CH 2）P O - [（CH 2）2 -O] q- ， - （CH 2）r; （CH2）r-NCH3-（CH2）rO - ， - （CH2）rCO-NR' - [（CH2）2-O] s-， - （CH 2）r NCH 3 - [（CH 2）2 -O] S - ，R'为H或CH 3，n为1至5的整数，p为1至2的整数，q为整数 数字范围从1到4，r是范围从1到3的整数，r'是范围从1到3的整数，s是范围从1到3的整数，n，p，q，r，r '和s是相同的或不同的，吡咯环在2,3,4或5位取代。
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