公开(公告)号：EP1115466A4

公开(公告)日：2001-11-28

申请号：EP99934056

申请日：1999-07-14

申请人： BIOTAGE INC

发明人： LALLY MICHAEL T ,  LEAVESLEY PETER J ,  LOCKMAN ROBERT D ,  VANDAVELAAR PETER C

IPC分类号： B01D15/08 ,  G01N30/02 ,  G01N30/46 ,  G01N30/52 ,  G01N30/60 ,  G01N30/84

CPC分类号： G01N30/6026 ,  G01N30/466 ,  G01N30/6043 ,  G01N30/6047 ,  G01N2030/027 ,  G01N2030/522

摘要： An apparatus and method for sealing a plurality of columns (12) containing media (14) for use in liquid chromatography. The invention involves two sealing assemblies (18, 20), each having a plurality of sealing heads (22). The sealing heads (22) are sized to receive ends of the columns (12) and to seal the columns (12) when the heads (12) are compressed. Compressive force is exerted by or through springs (44) to permit the sealing heads (22) to adapt to the length of the media bed (14) within each column (12). The apparatus may include a pressure containment vessel (10) for subjecting the columns (12) to radial compression.