公开(公告)号：EP2028187A1

公开(公告)日：2009-02-25

申请号：EP08016646.5

申请日：2001-09-07

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： Arap, Wadih ,  Pasqualini, Renata

IPC分类号： C07K7/00 ,  C07K7/04 ,  C07K17/02 ,  A61K39/00 ,  A61K38/03 ,  A61K38/04

CPC分类号： C07K14/52 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/5256 ,  C07K1/047 ,  C07K7/06 ,  C12N15/1037 ,  C12N2810/40 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/414 ,  Y02A50/478

摘要： The present invention concerns methods and compositions for in vivo and in vitro targeting. A large number of targeting peptides directed towards human organs, tissues or cell types are disclosed. The peptides are of use for targeted delivery of therapeutic agents, including but not limited to gene therapy vectors. A novel class of gene therapy vectors is disclosed. Certain of the disclosed peptides have therapeutic use for inhibiting angiogenesis, inhibiting tumor growth, inducing apoptosis, inhibiting pregnancy or inducing weight loss. Methods of identifying novel targeting peptides in humans, as well as identifying endogenous receptor-ligand pairs are disclosed. Methods of identifying novel infectious agents that are causal for human disease states are also disclosed. A novel mechanism for inducing apoptosis is further disclosed.

摘要翻译： 本发明涉及用于体内和体外靶向的方法和组合物。 公开了大量针对人器官，组织或细胞类型的靶向肽。 肽可用于靶向递送治疗剂，包括但不限于基因治疗载体。 公开了一类新型的基因治疗载体。 某些所公开的肽具有抑制血管生成，抑制肿瘤生长，诱导凋亡，抑制妊娠或引起体重减轻的治疗用途。 公开了鉴定人中新靶向肽的方法，以及鉴定内源性受体 - 配体对。 还公开了鉴定对人类疾病状态有影响的新型感染因子的方法。 进一步公开了诱导细胞凋亡的新机制。