专利检索 ap:("BOEHRINGER INGELHEIM INTERNATIONAL GMBH" OR "Boehringer Ingelheim Pharma GmbH & Co. KG") AND inv:"COLLET, Rosemarie" 第 1 页

1.

发明公开
VERFAHREN ZUR HERSTELLUNG VON N-ALKYL-N-METHYL-3-HYDROXY-3-(2-THIENYL)-PROPYLAMINEN 审中-公开
标题翻译：工艺用于制备N-烷基N-甲基-3-羟基-3-（2-噻吩基）-PROPYLAMINEN

公开(公告)号：EP1789385A1

公开(公告)日：2007-05-30

申请号：EP05707642.4

申请日：2005-02-26

申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , Boehringer Ingelheim Pharma GmbH & Co. KG

发明人： SCHIFFERS, Robert , KREYE, Paul , BAUMGARTEN, Wolfgang , COLLET, Rosemarie

IPC分类号： C07D201/00

CPC分类号： C07D333/16

摘要： The invention relates to an improved method for the production of chiral N-substituted N-methyl-3-hydroxy-3-(2-thienyl)-propylamine, on an industrial scale by using asymmetric hydrogenation as a key step and, optionally, a special sequence of successive steps. A catalyst system consisting of rhodium and (2R, 4R)-4-(dicyclohexylphosphino)-2-(diphenyl-phosphino-methyl)-N-methyl-aminocarbonyl-pyrrolidine is used.