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1.发明授权VERWENDUNG VON TYROSINKINASE-INHIBITOREN ZUR BEHANDLUNG INFLAMMATORISCHER PROZESSE 有权酪氨酸激酶抑制剂用于治疗炎性过程USE
公开(公告)号：EP1682147B1
公开(公告)日：2009-10-07
申请号：EP04790780.3
申请日：2004-10-23
发明人： JUNG, Birgit , PUESCHNER, Hubert
IPC分类号： A61K31/517 , A61P29/00 , A61P1/00
CPC分类号： A61K31/517
摘要： The invention relates to the use of selected quinazoline, tautomers thereof, stereoisomers and salts thereof, particularly physiologically compatible salts thereof having inorganic or organic acids or bases, for the production of a medicament in order to prevent or treat diseases of the respiratory tracts or lungs, in addition to other inflammatory diseases.
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2.发明公开BICYCLISCHE HETEROCYCLEN, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL, DEREN VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG 审中-公开BICYCLISCHE HETEROCYCLEN，DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL，DEREN VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG
公开(公告)号：EP1966189A1
公开(公告)日：2008-09-10
申请号：EP06819573.4
申请日：2006-11-17
IPC分类号： C07D401/12 , C07D239/94 , A61K31/517 , A61P35/00
CPC分类号： C07D401/12 , C07D239/94
摘要： The invention relates to bicyclic heterocycles of general formula (I), the tautomers thereof, the mixtures and salts thereof, especially the physiologically acceptable salts thereof comprising inorganic or organic acids, which have valuable pharmaceutical properties, particularly an inhibitive effect on signal transduction mediated by tyrosine kinases, the use thereof for treating diseases, especially tumor diseases and benign prostatic hyperplasia (BPH), lung diseases, and respiratory tract diseases, and the production thereof.
摘要翻译： 本发明涉及通式（I）的双环杂环化合物，其互变异构体，其混合物和盐，特别是其生理上可接受的盐，其包含无机酸或有机酸，其具有有价值的药学性质，特别是对由以下介导的信号转导的抑制作用： 酪氨酸激酶，其用于治疗疾病，特别是肿瘤疾病和良性前列腺增生（BPH），肺疾病和呼吸道疾病的用途及其制备。
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3.发明公开VERWENDUNG VON SUBSTITUIERTEN PTERIDINEN ZUR BEHANDLUNG VON ATEMWEGSERKRANKUNGEN 审中-公开取代蝶啶类的呼吸系统疾病治疗中的应用
公开(公告)号：EP1708715A1
公开(公告)日：2006-10-11
申请号：EP05700802.1
申请日：2005-01-11
发明人： NICKOLAUS, Peter , MEADE, Christopher J. Montague , DOLLINGER, Horst , MACK, Jürgen , DAHMANN, Georg , MARTYRES, Domnic , JUNG, Birgit
IPC分类号： A61K31/519 , A61P11/00 , A61P11/06
CPC分类号： A61K31/525 , A61K31/519 , A61K31/5377 , A61K31/541
摘要： The invention relates to the use of pteridines for the treatment of inflammatory and obstructive diseases of the respiratory tract, preferably asthma or COPD, and pharmaceutical compounds containing said compounds.
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4.发明公开VERWENDUNG VON TYROSINKINASE-INHIBITOREN ZUR BEHANDLUNG INFLAMMATORISCHER PROZESSE 有权酪氨酸激酶抑制剂用于治疗炎性过程USE
公开(公告)号：EP1682147A1
公开(公告)日：2006-07-26
申请号：EP04790780.3
申请日：2004-10-23
发明人： JUNG, Birgit , PUESCHNER, Hubert
IPC分类号： A61K31/517 , A61P29/00 , A61P1/00
CPC分类号： A61K31/517
摘要： The invention relates to the use of selected quinazoline, tautomers thereof, stereoisomers and salts thereof, particularly physiologically compatible salts thereof having inorganic or organic acids or bases, for the production of a medicament in order to prevent or treat diseases of the respiratory tracts or lungs, in addition to other inflammatory diseases.
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5.发明公开VERWENDUNG VON CHINAZOLIN TYROSINKINASE-INHIBITOREN ZUR BEHANDLUNG INFLAMMATORISCHER PROZESSE 审中-公开- 喹唑啉酪氨酸激酶抑制剂用于治疗炎性过程USE
公开(公告)号：EP1651228A1
公开(公告)日：2006-05-03
申请号：EP04763394.6
申请日：2004-07-22
发明人： JUNG, Birgit , PUESCHNER, Hubert
IPC分类号： A61K31/517 , A61P29/00 , A61P1/00
CPC分类号： A61K31/517 , A61K31/5377
摘要： The invention relates to the use of selected quinazolines, tautomers, stereoisomeres and salts thereof, especially the physiologically compatible salts thereof with inorganic or organic acids or bases, in the production of a medicament for the prophylaxis or treatment of illnesses of the respiratory tracts or lungs and additional inflammatory illnesses.
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6.发明公开DIHYDROTHIENOPYRIMIDINE ZUR BEHANDLUNG VON ENTZÜNDLICHEN ERKRANKUNGEN 有权Dihydrothienopyrimidines炎症性疾病的治疗
公开(公告)号：EP1874781A1
公开(公告)日：2008-01-09
申请号：EP06743350.8
申请日：2006-04-19
IPC分类号： C07D495/04 , A61P11/00 , A61K31/519
CPC分类号： C07D521/00 , C07D495/04 , C07D519/00
摘要： The invention relates to novel dihydrothienopyrimidines of formula (1) as well as pharmaceutically acceptable salts, diastereomers, enantiomers, racemates, hydrates, or solvates thereof, which are suitable for the treatment of ailments or diseases of the respiratory tract, gastrointestinal ailments or diseases, inflammatory diseases of the joints, skin, or eyes, diseases of the peripheral or central nervous system, or cancer diseases. Also disclosed are pharmaceutical compositions containing the inventive compounds.
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7.发明公开VERWENDUNG VON TYROSINKINASE-INHIBITOREN ZUR BEHANDLUNG DER CHRONISCHEN RHINOSINUSITIS 审中-公开酪氨酸激酶抑制剂用于治疗慢性鼻窦炎USE
公开(公告)号：EP1845992A1
公开(公告)日：2007-10-24
申请号：EP06707722.2
申请日：2006-01-16
发明人： JUNG, Birgit , DISSE, Bernd , POHL, Gerald
IPC分类号： A61K31/517 , A61P11/00
CPC分类号： A61K31/517
摘要： The invention relates to the use of selected EGFR kinase inhibitors, especially selected quinazolines, quinolines, and pyrimidopyrimidines, for treating nasal polyposis and chronic rhinosinusitis.
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8.发明公开SUBSTITUIERTE PTERIDINE ZUR BEHANDLUNG VON ENTZ]NDLICHEN ERKRANKUNGEN 审中-公开SUTITANTERTE PTERIDINE ZUR BEHANDLUNG VON ENTZ] NDLICHEN ERKRANKUNGEN
公开(公告)号：EP1824854A2
公开(公告)日：2007-08-29
申请号：EP05823962.5
申请日：2005-11-25
IPC分类号： C07D475/08 , A61K31/519 , A61P35/00
CPC分类号： C07D475/08
摘要： The invention relates to novel pteridines which are suitable for treating respiratory or gastrointestinal complaints or diseases, joint, skin or eye inflammatory diseases, disease of the periphery or central nervous system or cancer. The invention also relates to pharmaceutical compositions containing said compounds.
摘要翻译： 本发明涉及适用于治疗呼吸或胃肠疾病，关节，皮肤或眼睛炎性疾病，外周或中枢神经系统疾病或癌症的新型蝶啶。 本发明还涉及含有所述化合物的药物组合物。
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9.发明授权
公开(公告)号：EP2029600B1
公开(公告)日：2012-03-14
申请号：EP07729158.1
申请日：2007-05-15
IPC分类号： C07D475/08 , A61K31/495 , A61P11/00 , A61P17/00 , A61P25/00 , A61P29/00 , A61P35/00
CPC分类号： C07D475/08
摘要： The invention relates to novel pteridines of formula (1), suitable for the treatment of airway or gastrointestinal complaints or diseases, inflammatory diseases of the joints, the skin or eyes, diseases of the peripheral or central nervous systems or cancerous diseases and pharmaceutical compositions comprising said compounds.
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10.发明公开EGFR KINASE INHIBITOR COMBINATIONS FOR THE TREATMENT OF RESPIRATORY AND GASTROINTESTINAL DISORDERS 审中-公开EGFR激酶抑制剂结合呼吸道和胃肠道疾病的治疗
公开(公告)号：EP2086641A2
公开(公告)日：2009-08-12
申请号：EP07821719.7
申请日：2007-10-23
发明人： JUNG, Birgit , HIMMELSBACH, Frank , POHL, Gerald
IPC分类号： A61P1/00 , A61P11/00 , A61K31/517 , A61K31/5375 , A61K31/55 , A61K45/06 , A61K9/00
CPC分类号： A61K9/0073 , A61K31/517 , A61K31/5375 , A61K31/55 , A61K45/06 , A61K2300/00
摘要： The present invention relates to novel pharmaceutical compositions comprising at least one EGFR kinase inhibitor and at least one additional active compound selected from beta-2 mimetics, steroids, PDE-IV inhibitors, p38 MAP kinase inhibitors, NK1 antagonists, anticholinergics and endothelin antagonists, processes for preparing the compositions and the use thereof as medicament in the treatment of respiratory or gastrointestinal complaints, as well as inflammatory diseases of the joints, the skin or the eyes.
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