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1.发明公开Crystalline forms of endo-2,3-dihydro-N-(8-methyl-8-azabicyclo 3.2.1 oct-3-yl)-2-oxo-1H-benzimidazole-1-carboxamide hydrochloride monohydrate and of endo-3-ethyl-2,3-dihydro-N-(8-methyl-8-azabicyclo 3.2.1 oct-3-yl)-2-oxo-1H-benzimidazole-1-carboxamide hydrochloride monohydrate as 5-HT antagonists 失效Kristalline Forme von Endo-2,3-Dihydro-N-18-甲基-8-氮杂双环（3.2.1）Oct-3-Y1）-2-氧代-1H-苯并咪唑-1-羧甲酰胺盐酸盐一水合物 - 乙基-2,3-二氢-N-（8-甲基-8-氮杂双环（3.2.1）Oct-3-Y1）-2-氧代-1H-苯并咪唑-1-甲酰胺盐酸盐一水合物5-HT拮抗剂。
公开(公告)号：EP0567767A1
公开(公告)日：1993-11-03
申请号：EP93104564.5
申请日：1993-03-19
IPC分类号： C07D451/04 , A61K31/46
CPC分类号： C07D451/04
摘要： Crystalline monohydrates of endo-2,3-dihydro-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-2-oxo-1H-benzimidazole-1-carboxamide hydrochloride and of endo-3-ethyl-2,3-dihydro-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-2-oxo-1H-benzimidazole-1-carboxamide hydrochloride of formula
(Compound 2a : R = H)
(Compound 2b : R = C₂H₅)
the processes for their preparation and pharmaceutical compositions containing them.摘要翻译： 内-2,3-二氢-N-（8-甲基-8-氮杂双环[3.2.1]辛-3-基）-2-氧代-1H-苯并咪唑-1-甲酰胺盐酸盐的结晶一水合物， 3-乙基-2,3-二氢-N-（8-甲基-8-氮杂双环[3.2.1]辛-3-基）-2-氧代-1H-苯并咪唑-1-甲酰胺盐酸盐 （化合物2a：R = H>（化合物2b：R = C2H5）其制备方法和含有它们的药物组合物。
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2.发明授权Crystalline forms of endo-2,3-dihydro-N-(8-methyl-8-azabicyclo (3.2.1)oct-3-yl)-2-oxo-1H-benzimidazole-1-carboxamide hydrochloride monohydrate and of endo-3-ethyl-2,3-dihydro-N-(8-methyl-8-azabicyclo (3.2.1) oct-3-yl)-2-oxo-1H-benzimidazole-1-carboxamide hydrochloride monohydrate as 5-HT antagonists 失效Kristalline Formen von Endo-2,3-二氢-N-（8-甲基-8-氮杂双环（3.2.1）Oct-3-基）-2-氧代-1H-苯并咪唑-1-甲酰胺盐酸盐水单盐酸盐 3-乙基-2,3-二氢-N-（8-甲基-8-氮杂双环（3.2.1）Oct3-基）-2-氧代-1H-苯并咪唑-1-甲酰胺盐酸盐一水合物5-HT拮抗剂
公开(公告)号：EP0567767B1
公开(公告)日：1998-07-29
申请号：EP93104564.5
申请日：1993-03-19
IPC分类号： C07D451/04 , A61K31/46
CPC分类号： C07D451/04
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