NUCLEIC ACID TRANFER PEPTIDES AND THEIR USE FOR INJECTING NUCLEIC ACIDS INTO EUCARYOTIC CELLS
    5.
    发明公开
    NUCLEIC ACID TRANFER PEPTIDES AND THEIR USE FOR INJECTING NUCLEIC ACIDS INTO EUCARYOTIC CELLS 失效
    核酸转移肽及其使用将核酸导入真核细胞

    公开(公告)号:EP0693939A1

    公开(公告)日:1996-01-31

    申请号:EP94913594.0

    申请日:1994-04-13

    IPC分类号: A61K47 C12N15

    CPC分类号: C12N15/87 A61K47/645

    摘要: A nucleic acid transfer peptide contains: (a) a first ligand selected in the group of peptides, steroids, carbohydrates, lipids or vitamins which binds to a binding partner at the surface of eucaryotic cells, triggering an endocytosis of the complex composed of said nucleic acid transfer peptide and a nucleic acid; (b) a second ligand selected in the group of peptides, steroids, carbohydrates, lipids or vitamines which binds to a binding partner on the outer membrane of the nucleus of eucaryotic cells; (c) a third ligand which is a basic peptide and binds to nucleic acids by ion exchange. These peptides are useful for injecting nucleic acids into eucaryotic cells.