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1.发明授权PREPARATION OF CHOLECYSTOKININ AGONISTS AND ANTAGONISTS AND THEIR THERAPEUTIC AND DIAGNOSTIC USE 有权胆囊收缩素及治疗和诊断使用激动剂和拮抗剂的生产
公开(公告)号：EP1390405B1
公开(公告)日：2007-01-24
申请号：EP02743064.4
申请日：2002-05-21
IPC分类号： C07K14/595 , G01N33/68 , A61K38/22 , A61P35/00 , A61K49/14 , A61K51/08 , A61K103/10
CPC分类号： A61K38/12 , A61K49/0002 , A61K51/088 , C07K14/595 , G01N33/532 , G01N33/534 , G01N33/58 , G01N33/60
摘要： This patent application describes the preparation of cyclic and branched peptides of general formula (I) and their conjugated derivatives labelled with a paramagnetic or radioactive metal. The compounds of the present invention are used as diagnostic agents to identify and locate primary tumours and their metastases which over-express type A and/or B cholecystokinin receptors, and as therapeutic agents and cholecystokinin agonists or antagonists.
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2.发明授权
公开(公告)号：EP1412383B1
公开(公告)日：2006-11-15
申请号：EP02764797.3
申请日：2002-07-26
发明人： AIME, Silvio , GIANOLIO, Eliana , MORELLI, Giancarlo , PEDONE, Carlo , TESAURO, Diego , LATTUADA, Luciano , VISIGALLI, Massimo , ANELLI, Pier, Lucio
IPC分类号： C07K14/595 , C07K14/655 , C07C237/12 , C07F9/38 , A61K38/04 , A61K51/08 , G01N33/68 , C07F9/572
CPC分类号： A61K49/14 , A61K49/085 , C07K14/595 , C07K14/655
摘要： The present invention relates to a novel class of contrast agents for use in nuclear magnetic resonance (MRI), to identify and locate primary human tumours and their metastases which over-express type CCK A and/or type B cholecystokinin receptors, and/or type SSTR 1-5 somatostatin receptors.
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3.发明公开PREPARATION OF CHOLECYSTOKININ AGONISTS AND ANTAGONISTS AND THEIR THERAPEUTIC AND DIAGNOSTIC USE 有权胆囊收缩素及治疗和诊断使用激动剂和拮抗剂的生产
公开(公告)号：EP1390405A2
公开(公告)日：2004-02-25
申请号：EP02743064.4
申请日：2002-05-21
IPC分类号： C07K14/595 , C07K5/12 , G01N33/68 , A61K38/22 , A61P35/00 , A61K49/14 , A61K51/08 , A61K103/10
CPC分类号： A61K38/12 , A61K49/0002 , A61K51/088 , C07K14/595 , G01N33/532 , G01N33/534 , G01N33/58 , G01N33/60
摘要： This patent application describes the preparation of cyclic and branched peptides of general formula (I) and their conjugated derivatives labelled with a paramagnetic or radioactive metal. The compounds of the present invention are used as diagnostic agents to identify and locate primary tumours and their metastases which over-express type A and/or B cholecystokinin receptors, and as therapeutic agents and cholecystokinin agonists or antagonists.
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4.发明授权
公开(公告)号：EP1412383B9
公开(公告)日：2007-10-03
申请号：EP02764797.3
申请日：2002-07-26
发明人： AIME, Silvio , GIANOLIO, Eliana , MORELLI, Giancarlo , PEDONE, Carlo , TESAURO, Diego , LATTUADA, Luciano , VISIGALLI, Massimo , ANELLI, Pier, Lucio
IPC分类号： C07K14/595 , C07K14/655 , C07C237/12 , C07F9/38 , A61K38/04 , A61K51/08 , G01N33/68 , C07F9/572
CPC分类号： A61K49/14 , A61K49/085 , C07K14/595 , C07K14/655
摘要： The present invention relates to a novel class of contrast agents for use in nuclear magnetic resonance (MRI), to identify and locate primary human tumours and their metastases which over-express type CCK A and/or type B cholecystokinin receptors, and/or type SSTR 1-5 somatostatin receptors.
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5.发明公开
公开(公告)号：EP1412383A2
公开(公告)日：2004-04-28
申请号：EP02764797.3
申请日：2002-07-26
发明人： AIME, Silvio , GIANOLIO, Eliana , MORELLI, Giancarlo , PEDONE, Carlo , TESAURO, Diego , LATTUADA, Luciano , VISIGALLI, Massimo , ANELLI, Pier, Lucio
IPC分类号： C07K14/595 , C07K14/655 , C07C237/12 , C07F9/38 , A61K38/04 , A61K51/08 , G01N33/68 , C07F9/572
CPC分类号： A61K49/14 , A61K49/085 , C07K14/595 , C07K14/655
摘要： The present invention relates to a novel class of contrast agents for use in nuclear magnetic resonance (MRI), to identify and locate primary human tumours and their metastases which over-express type CCK A and/or type B cholecystokinin receptors, and/or type SSTR 1-5 somatostatin receptors.
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