公开(公告)号：EP0630384A4

公开(公告)日：1996-09-04

申请号：EP93907073

申请日：1993-03-01

申请人： BRIGHAM & WOMENS HOSPITAL ,  BETH ISRAEL HOSPITAL

发明人： STROM TERRY ,  RUBIN-KELLEY VICKIE E ,  LIBERMANN TOWIA

IPC分类号： C12N15/09 ,  A61K31/70 ,  A61K38/00 ,  A61K48/00 ,  A61P37/06 ,  C07H21/04 ,  C07K14/47 ,  C07K14/495 ,  C07K14/52 ,  C07K14/54 ,  C07K14/705 ,  C07K14/715 ,  C07K15/00 ,  C07H15/12

CPC分类号： C07K14/54 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4703 ,  C07K14/4713 ,  C07K14/495

摘要： Disclosed is a method of preventing graft rejection by inducing a state of local immunosuppression at the transplant site with expression of recombinant proteins by the allograft. Also disclosed is a protein suppressor factor that is secreted by cloned anergic T-cells, blocks interleukin 2 (IL-2) stimulated T-cell proliferation, has an apparent molecular weight of between 10 and 30 kilodaltons, can be inactivated by heating to 65 DEG C for 15 minutes, blocks interleukin 4 (IL-4) stimulated T-cell proliferation in vitro, is non-cytotoxic to T-cells, and does not inhibit the production of IL-2 by T-cells in vitro.

公开(公告)号：EP2596023A4

公开(公告)日：2014-03-05

申请号：EP11810339

申请日：2011-07-20

申请人： BETH ISRAEL HOSPITAL

发明人： STROM TERRY ,  KOULMANDA MARIA

IPC分类号： C07K16/24 ,  A61K38/20 ,  A61K39/395 ,  A61K45/06 ,  A61P37/00 ,  C07K14/54 ,  C07K16/28 ,  C07K16/46 ,  C12N15/24

CPC分类号： A61K39/3955 ,  A61K38/20 ,  A61K45/06 ,  C07K14/54 ,  C07K16/248 ,  C07K16/468 ,  C07K2317/76 ,  C07K2319/30 ,  A61K2300/00