公开(公告)号：EP2970311A4

公开(公告)日：2016-11-23

申请号：EP14775808

申请日：2014-03-13

申请人： BRIGHAM & WOMENS HOSPITAL ,  US HEALTH

发明人： ALIMARDANOV ASAF ,  CUNY GREGORY D ,  GREWAL GURMIT SINGH ,  LEE ARTHUR ,  MCKEW JOHN C ,  MOHEDAS AGUSTIN H ,  SHEN MIN ,  XU XIN ,  YU PAUL B

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61K31/5377 ,  A61P5/30 ,  A61P9/10 ,  A61P27/00 ,  A61P29/00 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00

CPC分类号： C07D487/04 ,  C07D519/00

摘要： The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds may also be used to reduce circulating levels of ApoB-100 or LDL and treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia.