专利检索 ap:("BSIM THERAPEUTICS, S.A.") AND inv:"OLIVEIRA NASCIMENTO, Bruno Filipe" 第 1 页

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发明公开
2-OXOTHIAZOLIDIN-4-ONE DERIVATIVES ACTIVE AS TRANSTHYRETIN LIGANDS AND USES THEREOF 审中-公开

公开(公告)号：EP4029859A1

公开(公告)日：2022-07-20

申请号：EP21192238.0

申请日：2015-11-20

申请人： BSIM THERAPEUTICS, S.A.

发明人： PONTES MEIRELES FERREIRA DE BRITO, Rui Manuel , VIEIRA SIMÕES, Carlos Jose , VASCONCELOS DIAS DE PINHO MELO, Teresa Margarida , DA SILVA VICTOR, Bruno Lourenço , LOURENÇO DE ALMEIDA, Zaida Catarina , CABRAL CARDOSO LOPES, Ana Lucia , OLIVEIRA NASCIMENTO, Bruno Filipe

IPC分类号： C07D277/34 , A61K31/426 , A61P25/28

摘要： Compounds of formula (II) are provided for stabilizing protein transthyretin (TTR) and inhibiting amyloid fibril formation, for example, transthyretin-mediated amyloid fibril formation, and for treating, preventing, or ameliorating one or more symptoms of amyloid diseases, for example, transthyretin-related amyloidosis (ATTR).