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公开(公告)号：EP4386763A3
公开(公告)日：2024-08-14
申请号：EP23217163.7
申请日：2014-03-14
发明人： YOUNG, Brian A. , MINARD-SMITH, Angela T. , HEIZER, Esley M., Jr. , BORNMAN, Daniel M. , HESTER, Mark E. , YANG, Boyu
摘要： In one illustrative embodiment, a method may comprise receiving a first text-based computer file including one or more records, each of the one or more records comprising nucleotide sequence data generated by a read of a massively parallel sequencing instrument, determining whether a portion of the nucleotide sequence data of each record represents a short tandem repeat (STR) associated with a locus, placing each portion of the nucleotide sequence data determined to represent an STR associated with a locus into one of a number of locus-specific lists, determining a number of occurrences within each locus-specific list of identical nucleotide sequence data representing a unique STR, and generating a second text-based computer file including one or more records, each of the one or more records corresponding to a unique STR for which the number of occurrences of identical nucleotide sequence data representing the unique STR exceeded an abundance threshold.
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公开(公告)号：EP4386763A2
公开(公告)日：2024-06-19
申请号：EP23217163.7
申请日：2014-03-14
发明人： YOUNG, Brian A. , MINARD-SMITH, Angela T. , HEIZER, Esley M., Jr. , BORNMAN, Daniel M. , HESTER, Mark E. , YANG, Boyu
IPC分类号： G16B30/00
摘要： In one illustrative embodiment, a method may comprise receiving a first text-based computer file including one or more records, each of the one or more records comprising nucleotide sequence data generated by a read of a massively parallel sequencing instrument, determining whether a portion of the nucleotide sequence data of each record represents a short tandem repeat (STR) associated with a locus, placing each portion of the nucleotide sequence data determined to represent an STR associated with a locus into one of a number of locus-specific lists, determining a number of occurrences within each locus-specific list of identical nucleotide sequence data representing a unique STR, and generating a second text-based computer file including one or more records, each of the one or more records corresponding to a unique STR for which the number of occurrences of identical nucleotide sequence data representing the unique STR exceeded an abundance threshold.
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公开(公告)号：EP4307307A3
公开(公告)日：2024-03-27
申请号：EP23205000.5
申请日：2015-09-02
发明人： YOUNG, Brian A. , HEIZER, JR., Esley M. , MINARD-SMITH, Angela T. , MCMILLAN, Nancy J. , YAVAS, Gokhan , BORNMAN, Daniel M.
摘要： In at least one illustrative embodiment, a method may comprise selecting a first plurality of text strings that each represent a nucleotide sequence that was read by a massively parallel sequencing instrument, where the nucleotide sequences represented by the selected first plurality of text strings each correspond to a first target locus, comparing the selected first plurality of text strings to one another to determine an abundance count for each unique text string included in the selected first plurality of text strings, identifying a first number of unique text strings included in the selected first plurality of text strings as representing noise responses, and determining a method detection limit as a function of the abundance counts for the first number of unique text strings identified as representing noise responses.
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公开(公告)号：EP3195169A1
公开(公告)日：2017-07-26
申请号：EP15764021.0
申请日：2015-09-02
发明人： YOUNG, Brian A. , HEIZER, JR., Esley M. , MINARD-SMITH, Angela T. , MCMILLAN, Nancy J. , YAVAS, Gokhan , BORNMAN, Daniel M.
CPC分类号： G06F19/22
摘要： In at least one illustrative embodiment, a method may comprise selecting a first plurality of text strings that each represent a nucleotide sequence that was read by a massively parallel sequencing instrument, where the nucleotide sequences represented by the selected first plurality of text strings each correspond to a first target locus, comparing the selected first plurality of text strings to one another to determine an abundance count for each unique text string included in the selected first plurality of text strings, identifying a first number of unique text strings included in the selected first plurality of text strings as representing noise responses, and determining a method detection limit as a function of the abundance counts for the first number of unique text strings identified as representing noise responses.
摘要翻译： 在至少一个说明性实施例中，一种方法可以包括选择第一多个文本串，每个文本串表示由大规模并行测序仪阅读的核苷酸序列，其中由所选第一多个文本串表示的核苷酸序列各自对应于 第一目标轨迹，将所选择的第一多个文本串彼此进行比较以确定包括在所选择的第一多个文本串中的每个唯一文本串的丰度计数，识别包括在所选择的第一多个文本串中的第一数量的唯一文本串 作为表示噪声响应的文本串，并且确定方法检测极限作为被识别为表示噪声响应的第一数量的唯一文本串的丰度计数的函数。
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公开(公告)号：EP4307307A2
公开(公告)日：2024-01-17
申请号：EP23205000.5
申请日：2015-09-02
发明人： YOUNG, Brian A. , HEIZER, JR., Esley M. , MINARD-SMITH, Angela T. , MCMILLAN, Nancy J. , YAVAS, Gokhan , BORNMAN, Daniel M.
IPC分类号： G16B30/00
摘要： In at least one illustrative embodiment, a method may comprise selecting a first plurality of text strings that each represent a nucleotide sequence that was read by a massively parallel sequencing instrument, where the nucleotide sequences represented by the selected first plurality of text strings each correspond to a first target locus, comparing the selected first plurality of text strings to one another to determine an abundance count for each unique text string included in the selected first plurality of text strings, identifying a first number of unique text strings included in the selected first plurality of text strings as representing noise responses, and determining a method detection limit as a function of the abundance counts for the first number of unique text strings identified as representing noise responses.
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公开(公告)号：EP3637422A1
公开(公告)日：2020-04-15
申请号：EP19199379.9
申请日：2014-03-14
发明人： YOUNG, Brian A. , MINARD-SMITH, Angela T. , HEIZER, Esley M. Jr. , BORNMAN, Daniel M. , HESTER, Mark E. , YANG, Boyu
摘要： In one illustrative embodiment, a method may comprise receiving a first text-based computer file including one or more records, each of the one or more records comprising nucleotide sequence data generated by a read of a massively parallel sequencing instrument, determining whether a portion of the nucleotide sequence data of each record represents a short tandem repeat (STR) associated with a locus, placing each portion of the nucleotide sequence data determined to represent an STR associated with a locus into one of a number of locus-specific lists, determining a number of occurrences within each locus-specific list of identical nucleotide sequence data representing a unique STR, and generating a second text-based computer file including one or more records, each of the one or more records corresponding to a unique STR for which the number of occurrences of identical nucleotide sequence data representing the unique STR exceeded an abundance threshold.
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