公开(公告)号：EP0817858A1

公开(公告)日：1998-01-14

申请号：EP96907398.0

申请日：1996-03-08

申请人： Bavarian Nordic Research Institute a/s ,  GSF-Forschungszentrum für Umwelt und Gesundheit GmbH

发明人： GÜNZBURG, Walter, H. ,  WINDER, David ,  SALLER, Robert, Michael

IPC分类号： C12N15 ,  A61K35 ,  A61K38 ,  A61K39 ,  A61K48 ,  A61P31 ,  C07K14 ,  C12N7 ,  C12R1

CPC分类号： C12N15/86 ,  A61K48/00 ,  C07K14/43563 ,  C07K14/43572 ,  C12N2740/13043

摘要： The present invention relates to retroviral vectors carrying sequences encoding naturally occuring, antimicrobial peptides or derivatives thereof for the treatment of mammalian tumours, viral infections such as HIV infection and bacterial and fungal infections. In particular the present invention relates to retroviral vectors which undergo promoter conversion (Procon vectors) carrying such sequences. Since these vectors also carry tumour or virus specific regulatory elements, the therapeutic antimicrobial peptide will be delivered and expressed only in relevant, affected cells and not in innocent bystander cells.

公开(公告)号：EP0817858B1

公开(公告)日：2003-04-23

申请号：EP96907398.0

申请日：1996-03-08

申请人： Austrian Nordic Biotherapeutics AG ,  GSF-Forschungszentrum für Umwelt und Gesundheit GmbH

发明人： GÜNZBURG, Walter, H. ,  WINDER, David ,  SALLER, Robert, Michael

IPC分类号： C12N15/86 ,  A61K38/17 ,  A61K48/00

CPC分类号： C12N15/86 ,  A61K48/00 ,  C07K14/43563 ,  C07K14/43572 ,  C12N2740/13043

摘要： The present invention relates to retroviral vectors carrying sequences encoding naturally occuring, antimicrobial peptides or derivatives thereof for the treatment of mammalian tumours, viral infections such as HIV infection and bacterial and fungal infections. In particular the present invention relates to retroviral vectors which undergo promoter conversion (Procon vectors) carrying such sequences. Since these vectors also carry tumour or virus specific regulatory elements, the therapeutic antimicrobial peptide will be delivered and expressed only in relevant, affected cells and not in innocent bystander cells.