公开(公告)号：EP3682897A1

公开(公告)日：2020-07-22

申请号：EP19211162.3

申请日：2013-07-11

申请人： Baxalta GmbH ,  Baxalta Incorporated

发明人： Barrett, Noel P. ,  Aichinger, Gerald ,  Crowe, Brian A. ,  Livey, Ian ,  Wressnigg, Nina

IPC分类号： A61K39/02 ,  C07K16/12 ,  A61P31/04

摘要： The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.