公开(公告)号：EP3708581A1

公开(公告)日：2020-09-16

申请号：EP19198667.8

申请日：2010-05-27

申请人： Baxalta GmbH ,  Baxalta Incorporated

发明人： Teschner, Wolfgang, Dr. ,  Butterweck, Harald Arno ,  Pljevljakovic, Azra ,  Bauer, Theresa Friederike ,  Koelbl, Bernhard ,  Schwarz, Hans-Peter ,  Nikolic, Nebojsa ,  Poelsler, Gerhard ,  Kindermann, Johanna

IPC分类号： C07K16/06 ,  B01D61/14

摘要： The present invention relates to a new and improved method for preparing a highly concentrated immunoglobulin composition from pooled plasma for subcutaneous injection. A composition comprising 20% or more immunoglobulin suitable for subcutaneous use is also described.

公开(公告)号：EP3623377A1

公开(公告)日：2020-03-18

申请号：EP19204540.9

申请日：2014-03-14

申请人： Baxalta Incorporated ,  Baxalta GmbH

发明人： Hofbauer, Lucia ,  Butterweck, Harald Arno ,  Bauer, Theresa ,  Weber, Alfred ,  Teschner, Wolfgang ,  Schwarz, Hans-Peter

IPC分类号： C07K1/18 ,  C07K16/06 ,  B01D15/36 ,  B01D15/16 ,  B01D15/42 ,  C07K16/18 ,  C07K16/28

摘要： The present invention provides, among other aspects, methods for the manufacture of plasma-derived immunoglobulin G compositions highly enriched for anti-brain disease related protein antibodies (e.g., anti-Aβ, anti-RAGE, and anti-α-synuclein antibodies). Advantageously, the methods provided do not affect the manufacturing processes or capabilities for producing plasma-derived IgG therapeutics. Plasma-derived IgG compositions that are highly enriched for anti-brain disease related protein antibodies (e.g., anti-Aβ, anti-RAGE, and anti-α-synuclein antibodies), as also provided here. Methods for the treatment of brain diseases and disorders by administration of plasma-derived IgG compositions highly enriched for anti-brain disease related protein antibodies (e.g., anti-Aβ, anti-RAGE, and anti-α-synuclein antibodies), are also provided.