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    TREATMENT OF ALZHEIMER'S DISEASE SUBPOPULATIONS WITH POOLED IMMUNOGLOBULIN G
    1.
    发明公开
    TREATMENT OF ALZHEIMER'S DISEASE SUBPOPULATIONS WITH POOLED IMMUNOGLOBULIN G 有权
    百灵达茉莉花 - 阿尔茨海默 - 多囊卵单分枝杆菌GEPOOLTEM IMMUNGLOBULIN G

    公开(公告)号：EP2994160A1

    公开(公告)日：2016-03-16

    申请号：EP14730660.9

    申请日：2014-05-05

    申请人： Baxalta Incorporated ,  Baxalta GmbH

    发明人： GELMONT, David, M. ,  SINGER, Julia ,  FRITSCH, Sandor ,  SCHWARZ, Hans-Peter

    IPC分类号： A61K39/00

    CPC分类号： C07K16/18 ,  A61K38/47 ,  A61K39/39516 ,  A61K2039/505 ,  C07K16/06 ,  C07K16/065 ,  G01N33/6896

    摘要： The present invention provides, among other aspects, methods for the treatment of Alzheimer's disease in a subject in need thereof, the method including administration of a therapeutically effective amount of a pooled human immunoglobulin G (IgG) composition to a subject with moderately severe Alzheimer's disease, a subject carrying an ApoE4 allele, or both, where the amount of pooled human IgG is from 300 mg/kg to 800 mg/kg body weight of the subject per two week period, and where the amount is administered in one or more doses during the two week period after initiation of a therapeutic regimen. Also provided, are methods for selecting a treatment regimen for a subject with Alzheimer's disease, including diagnosing the severity of the Alzheimer's disease, determining if the subject carries an APOE4 allele, or both, and assigning a treatment regimen including administration of pooled human immunoglobulin G and/or an anti-beta amyloid monoclonal antibody.

    摘要翻译： 除其他方面外，本发明还提供了在有需要的受试者中治疗阿尔茨海默氏病的方法，所述方法包括将治疗有效量的合并的人免疫球蛋白G（IgG）组合物施用于具有中度严重阿尔茨海默病的受试者 ，携带ApoE4等位基因或两者的受试者，其中合并的人IgG的量为每两周的受试者的300mg / kg至800mg / kg体重，并且其中所述量以一个或多个剂量 在开始治疗方案后的两周期间。 还提供了用于选择患有阿尔茨海默病的受试者的治疗方案的方法，包括诊断阿尔茨海默氏病的严重程度，确定受试者是否携带APOE4等位基因或两者，以及分配治疗方案，包括给予合并的人免疫球蛋白G 和/或抗β淀粉样蛋白单克隆抗体。