专利检索 ap:("Baxalta Incorporated" OR "Baxalta GmbH" OR "Katholieke Universiteit Leuven") AND inv:"DENORME, Frederik" 第 1 页

1.

发明公开
COMPOSITIONS COMPRISING ADAMTS13 FOR USE IN METHODS FOR THE RECANALIZATION OF OCCLUDED BLOOD VESSELS IN AN INFARCTION 审中-公开
标题翻译：包含ADAMTS的组合物13用于在梗塞中再闭塞闭塞的血管的方法

公开(公告)号：EP3302533A1

公开(公告)日：2018-04-11

申请号：EP16729425.5

申请日：2016-05-26

申请人： Baxalta Incorporated , Baxalta GmbH , Katholieke Universiteit Leuven

发明人： PLAIMAUER, Barbara , ROTTENSTEINER, Hanspeter , SCHEIFLINGER, Friedrich , DE MEYER, Simon , DENORME, Frederik

IPC分类号： A61K38/48 , A61P9/10

CPC分类号： A61K38/4886 , A61P9/10 , C12Y304/24087

摘要： Provided herein are methods for recanalization of occluded blood vessels in a subject having an infarction. The method includes a step of administering to the subject a therapeutically effective amount of isolated ADAMTS13 protein at particular dosages and ranges of times after detection of the infarction. As described herein, ADAMTS13 advantageously recanalizes occluded blood vessels and reduces infarction size, even when administered a prolonged period after stable occlusion. Accordingly, such methods and compositions are useful for the treatment of infractions caused by blood vessel occlusion.