公开(公告)号：EP2820042A2

公开(公告)日：2015-01-07

申请号：EP13709675.6

申请日：2013-02-28

申请人： Baxter International Inc ,  Baxter Healthcare S.A.

发明人： KUERY, Patrick ,  TZEKOVA, Nevena ,  HARTUNG, Hans-peter ,  HERMANN, Corinna ,  REIPERT, Birgit Maria ,  SCHWARZ, Hans-peter ,  EHRLICH, Hartmut ,  BUNK, Sebastian

IPC分类号： C07K16/06 ,  A61P25/00

CPC分类号： C07K16/06 ,  A61K39/39516 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/065 ,  A61K2300/00

摘要： The present invention is based on the discovery of polyclonal IgG's ability to promote Schwann cell maturation, differentiation, and myelin production. Methods for treating non-idiopathic, demyelinating peripheral neuropathies in mammals, where the neuropathy is not immune-mediated or infection-mediated, through the administration of polyclonal IgG are provided. Types of demyelinating peripheral neuropathies treatable with the present invention include peripheral nerve trauma and toxin-induced peripheral neuropathies. Alternatively, a composition of polyclonal IgGs can be applied directly to a peripheral nerve cell to induce maturation, differentiation into a myelinating state, and myelin expression or promote cell survival.

摘要翻译： 本发明是基于多克隆IgG的促进雪旺氏细胞成熟，分化和髓鞘生成的能力的发现。 提供了通过施用多克隆IgG来治疗哺乳动物非特发性脱髓鞘外周神经病变的方法，其中神经病不是由免疫介导的或感染介导的。 可用本发明治疗的脱髓鞘周围神经病变的类型包括周围神经损伤和毒素诱导的周围神经病变。 或者，可以将多克隆IgG的组合物直接施用于周围神经细胞，以诱导成熟，分化成髓鞘状态和髓磷脂表达或促进细胞存活。