公开(公告)号：EP2480198A2

公开(公告)日：2012-08-01

申请号：EP10759786.6

申请日：2010-09-21

申请人： Baxter International Inc ,  Baxter Healthcare SA

发明人： MATTHIESSEN, H., Peter ,  TURECEK, Peter, L. ,  SCHWARZ, Hans-Peter

IPC分类号： A61K9/00 ,  A61K9/10 ,  A61K38/43 ,  A61K38/48

CPC分类号： A61K38/4886 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/19 ,  A61K47/02 ,  A61K47/10 ,  A61K47/183 ,  A61K47/22 ,  A61K47/26 ,  C12Y304/24087

摘要： The present invention relates to formulations of ADAMTS13 with enhanced or desirable properties. As such, the invention provides liquid and lyophilized formulations of ADAMTS13 that are suitable for pharmaceutical administration. Among other aspects, the present invention also provides methods of treating various diseases and conditions related to VWF and/or ADAMTS13 dysfunction in a subject. Also provided herein are kits comprising ADAMTS13 formulations useful for the treatment of various diseases and conditions.