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公开(公告)号：EP3700904A1
公开(公告)日：2020-09-02
申请号：EP18795421.9
申请日：2018-10-23
申请人： Bayer AG , BAYER PHARMA AKTIENGESELLSCHAFT , The Broad Institute, Inc. , Dana-Farber Cancer Institute Inc. et Al.
发明人： SIEGEL, Stephan , SIEGEL, Franziska , SCHULZE, Volker , BERGER, Markus , GRAHAM, Keith , KLAR, Ulrich , KNUT, Eis , SÜLZLE, Detlev , BÖMER, Ulf , KORR, Daniel , PETERSEN, Kirstin , MÖNNING, Ursula , EBERSPÄCHER, Uwe , MOOSMAYER, Dieter , MEYERSON, Matthew , GREULICH, Heidi , KAPLAN, Bethany , HARB, Hassan, Youssef , DINH, Phi, Manh
IPC分类号： C07D471/04 , A61P35/00 , A61K31/444 , A61K31/5377 , A61K31/4545
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公开(公告)号：EP4244225A1
公开(公告)日：2023-09-20
申请号：EP21830607.4
申请日：2021-11-09
申请人： Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft , The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc.
发明人： SIEGEL, Stephan , SIEGEL, Franziska , SCHULZE, Volker , BERGER, Markus , GRAHAM, Keith , KLAR, Ulrich , MORTIER, Jeremie Xavier G. , SÜLZLE, Detlev , BÖMER, Ulf , KORR, Daniel , SCHRÖDER, Jens , MEYERSON, Matthew , GREULICH, Heidi , KAPLAN, Bethany
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00 , A61P35/02
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公开(公告)号：EP4188929A1
公开(公告)日：2023-06-07
申请号：EP21759022.3
申请日：2021-07-27
发明人： SCHULZE, Volker , MENGEL, Anne , FARIA ALVARES DE LEMOS, Adelaide, Clara , RAUH, Ulrike , BÖMER, Ulf , HILLIG, Roman , LECHNER, Christian , MORTIER, Jeremie, Xavier, G. , SÜLZLE, Detlev , KAULFUSS, Stefan , CORSELLO, Steven , HANDING, Katarzyna , CALIMAN, Alisha , MADEC, Amael
IPC分类号： C07D471/04 , A61P35/00 , A61K31/437
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公开(公告)号：EP3959211A1
公开(公告)日：2022-03-02
申请号：EP20721196.2
申请日：2020-04-22
发明人： SIEGEL, Stephan , SIEGEL, Franziska , SCHULZE, Volker , BERGER, Markus , GRAHAM, Keith , SÜLZLE, Detlev , BÖMER, Ulf , KORR, Daniel , SCHRÖDER, Jens , MÖNNING, Ursula , NIEHUES, Michael , MEYERSON, Matthew , GREULICH, Heidi , KAPLAN, Bethany
IPC分类号： C07D471/04 , A61K31/4545 , A61P35/00
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公开(公告)号：EP3917915A1
公开(公告)日：2021-12-08
申请号：EP20703003.2
申请日：2020-01-30
发明人： GRADL, Stefan, Nikolaus , ELLERMANN, Manuel , LIENAU, Philip , KOPITZ, Charlotte, Christine , LANGE, Martin , TERSTEEGEN, Adrian , SÜLZLE, Detlev , LEWIS, Timothy, A. , GREULICH, Heidi , WU, Xiaoyun
IPC分类号： C07D253/06 , C07D403/10 , C07D403/12 , C07C229/08 , A61P35/00 , A61K31/53
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6.发明公开
公开(公告)号：EP3921317A1
公开(公告)日：2021-12-15
申请号：EP20706629.1
申请日：2020-02-06
发明人： SCHULZE, Volker , MENGEL, Anne , Schröder, Jens , FARIA ALVARES DE LEMOS, Adelaide, Clara , BONE, Wilhelm , BÖMER, Ulf , SÜLZLE, Detlev , CHRIST, Clara , HILLIG, Roman , LECHNER, Christian , CORSELLO, Steven , HANDING, Katarzyna , CALIMAN, Alisha , RAUH, Ulrike , KAULFUSS, Stefan , MORTIER, Jérémie
IPC分类号： C07D471/04 , C07D471/10 , A61K31/437 , A61P35/00
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公开(公告)号：EP4126861A1
公开(公告)日：2023-02-08
申请号：EP21715855.9
申请日：2021-03-25
发明人： SIEGEL, Stephan , SIEGEL, Franziska , SCHULZE, Volker , BERGER, Markus , MORTIER, Jeremie Xavier G. , SÜLZLE, Detlev , BÖMER, Ulf , KORR, Daniel , SCHRÖDER, Jens , MÖNNING, Ursula , NIEHUES, Michael , MEYERSON, Matthew , GREULICH, Heidi , KAPLAN, Bethany
IPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/5377 , A61K31/341 , A61K31/337 , A61K31/357 , A61K31/351 , A61K31/4545 , A61P35/00 , A61P35/02 , A61P35/04
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公开(公告)号：EP3959212A1
公开(公告)日：2022-03-02
申请号：EP20721506.2
申请日：2020-04-22
发明人： SIEGEL, Stephan , SIEGEL, Franziska , SCHULZE, Volker , BERGER, Markus , GRAHAM, Keith , GRADL, Stefan, Nikolaus , SÜLZLE, Detlev , BÖMER, Ulf , KORR, Daniel , SCHRÖDER, Jens , MÖNNING, Ursula , NIEHUES, Michael , MEYERSON, Matthew , GREULICH, Heidi , KAPLAN, Bethany , HARB, Hassan, Youssef , DINH, Phi, Manh
IPC分类号： C07D471/04 , A61K31/4545 , A61P35/00
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公开(公告)号：EP3571207A1
公开(公告)日：2019-11-27
申请号：EP18702420.3
申请日：2018-01-15
发明人： KLAR, Ulrich , BOHLMANN, Rolf , SCHÄCKE, Heike , SÜLZLE, Detlev , MENZ, Stephan , PANKNIN, Olaf
IPC分类号： C07D519/00 , A61K31/519 , A61P35/00 , C07D471/04 , A61K31/437 , A61P29/00
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公开(公告)号：EP3292107A1
公开(公告)日：2018-03-14
申请号：EP16721762.9
申请日：2016-05-02
发明人： EIS, Knut , ACKERSTAFF, Jens , WAGNER, Sarah , BUCHGRABER, Philipp , SÜLZLE, Detlev , HOLTON, Simon , BENDER, Eckhard , LI, Volkhart , LIU, Ningshu , SIEGEL, Franziska , LIENAU, Philip , BAIRLEIN, Michaela , VON NUSSBAUM, Franz , HERBERT,Simon , KOPPITZ, Marcus
IPC分类号： C07D233/54 , C07D263/34 , C07D401/12 , C07D403/06 , C07D405/12 , C07D413/06 , C07D417/06 , C07D487/14 , A61K31/38 , A61K31/4164 , A61K31/421 , A61K31/5025 , A61P35/00
CPC分类号： C07D233/90 , A61K31/4155 , A61K31/4164 , A61K31/4178 , A61K31/421 , A61K31/4439 , A61K31/454 , A61K31/5025 , A61K31/519 , A61K31/5377 , A61K31/554 , A61K45/06 , A61P35/00 , A61P35/04 , C07D233/54 , C07D263/34 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/06 , C07D417/12 , C07D487/04 , C07D487/10 , C07D487/14 , C07D491/107 , C07D495/10
摘要： The present invention relates to amido-substituted cyclohexane compounds of general formula (I), in which A, R4, R6, R7, R8, R9, R10 and R11 are as defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredient.
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