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24 条记录 (耗时 0.013 秒)

    A process for the manufacture of substituted triazolinones
    2.
    发明公开
    A process for the manufacture of substituted triazolinones 有权
    一种用于取代的三唑啉酮的制备方法

    公开(公告)号：EP1113010A1

    公开(公告)日：2001-07-04

    申请号：EP00127207.9

    申请日：2000-12-14

    申请人： Bayer Corporation

    发明人： Kulkarni, Shekhar V. ,  Desai, Vijay C. ,  Prasad, Vidyanatha A. ,  Rivadeneira, Eric ,  Jelich, Klaus

    IPC分类号： C07D249/12

    CPC分类号： C07D249/12

    摘要： The present invention relates to a process for manufacturing substituted triazolinones, which are intermediates in the preparation of herbicidally active compounds. In particular, this invention relates to the alkylation of a non-alkylated triazolinone intermediate product, wherein the improvement comprises conducting the alkylation reaction under pH controlled conditions. In a preferred embodiment, the invention relates to the preparation of a 5-alkoxy(or aryloxy)-2,4-dihydro-3H-1,2,4-triazol-3-one, and the alkylation of this non-alkylated triazolinone intermediate product, to produce a 5-alkoxy(or aryloxy)-4-alkyl-2,4-dihydro-3H-1,2,4-triazol-3-one.

    Process for the production of 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole
    3.
    发明公开
    Process for the production of 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole 有权
    Verfahren zur Herstellung von 2-（甲基磺酰基）-5-（三氟甲基）-1,3,4-噻二唑

    公开(公告)号：EP0987258A1

    公开(公告)日：2000-03-22

    申请号：EP99116876.6

    申请日：1999-09-06

    申请人： Bayer Corporation

    发明人： Prasad, Vidyanatha A. ,  Jelich, Klaus, Dr. ,  Hanson, Joe J.

    IPC分类号： C07D285/125

    CPC分类号： C07D285/125

    摘要： The present invention provides a process for making thiadiazole sulfones. In particular, the present process is used to make 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole using catalytic oxidation in the presence of a suitable oxidizing agent. The catalyst system used for the oxidation reaction is a mixture of glacial acetic acid and a tungsten catalyst. The tungsten catalyst is preferably selected from the group consisting of sodium tungstate, potassium tunstate, and tungstic acid.

    摘要翻译： 本发明提供了制备噻二唑砜的方法。 特别地，本方法用于在合适的氧化剂存在下使用催化氧化制备2-（甲基磺酰基）-5-（三氟甲基）-1,3,4-噻二唑。 用于氧化反应的催化剂体系是冰醋酸和钨催化剂的混合物。 钨催化剂优选选自钨酸钠，焦磷酸钾和钨酸。

    A process for making N-(4-fluorophenyl)-N-(1-methylethyl)-2-[(5-trifluoromethyl)-1,3,4-thiadiazol-2-yl)-oxy]-acetamide using an aprotic, aromatic solvent
    4.
    发明公开
    A process for making N-(4-fluorophenyl)-N-(1-methylethyl)-2-[(5-trifluoromethyl)-1,3,4-thiadiazol-2-yl)-oxy]-acetamide using an aprotic, aromatic solvent 有权
    [（5-（三氟甲基）-1,3,4-噻二唑-2-基） - 氧基]乙酰胺下 - 一种制备N-（4-氟苯基）-N-（1-甲基乙基）-2的过程 使用一种质子惰性的芳族溶剂的

    公开(公告)号：EP0927720A1

    公开(公告)日：1999-07-07

    申请号：EP98122759.8

    申请日：1998-12-01

    申请人： Bayer Corporation

    发明人： Prasad, Vidyanatha A. ,  Newallis, Peter E. ,  Wasleski, Daniel M. ,  Applegate, Jacqueline M. Dr. ,  Jelich, Klaus Dr.

    IPC分类号： C07D285/12

    CPC分类号： C07D285/12

    摘要： The present invention relates to a process for making N-(4-fluorophenyl)-N-(1-methylethyl)-2-[(5-trifluoromethyl)-1,3,4-thiadazol-2-yl)-oxy]-acetamide in an aprotic, aromatic solvent.
    The process includes the stepps of: (a) reacting 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole with N-(4-fluorophenyl)-N-(1-methylethyl)-2-hydroxyacetamide and an aqueous alkali in the presence of an aprotic, aromatic solvent to form an aqueous phase and an organic phase; (b) acidifying the phases, (c) separating the phases; and (d) recovering the N-(4-fluorophenyl)-N-(1-methylethyl)-2-[(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)-oxy]-acetamide from the organic phase.

    摘要翻译： N-新制备（4-氟苯基）-N-（1-甲基乙基）-2 - （（5-三氟甲基）-1,3,4-噻二唑-2-基）氧基）乙酰胺（I）使用，以非质子， 芳族溶剂。 N-（4-氟苯基）-N-（1-甲基乙基）-2的制备 - （（5-三氟甲基）-1,3,4-噻二唑-2-基）氧基）乙酰胺（Fluthiamide）的（i）包括： （a）使2-（甲基磺酰基）-5-（三氟甲基）-1,3,4-噻二唑与N-（4-氟苯基）在wässrige存在-2-羟基-N-（1-甲基乙基）乙酰胺 碱和质子惰性的芳族溶剂中以形成和wässrige相和有机相; （B）通过酸化加入无机酸的混合物; （C）分离各相; 和（d）从有机相中回收（I）。

    A process for producing N-(4-fluorophenyl)-N-(1-methylethyl)-2-[(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)-oxy]-acetamide
    5.
    发明公开
    A process for producing N-(4-fluorophenyl)-N-(1-methylethyl)-2-[(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)-oxy]-acetamide 有权
    [（5-（三氟甲基）-1,3,4-噻二唑-2-基） - 氧基]乙酰胺 - 一种N-（4-氟苯基）-N-（1-甲基乙基）-2的制备方法

    公开(公告)号：EP0922701A1

    公开(公告)日：1999-06-16

    申请号：EP98122758.0

    申请日：1998-12-01

    申请人： Bayer Corporation

    发明人： Prasad, Vidyanatha A. ,  Applegate, Jacqueline M. Dr. ,  Wasleski, Daniel M. ,  Jelich, Klaus Dr.

    IPC分类号： C07D285/13

    CPC分类号： C07D285/13

    摘要： The present invention relates to a process for making N-(4-fluorophenyl)-N-(1-methylethyl)-2-[(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)-oxy]-acetamide, which process includes the steps of reacting 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4,-thiadiazole with N-(4-fluorophenyl)-N-(1-methylethyl)-2-hydroxyacetamide in an aprotic, aromatic solvent with aqueous alkali to form an aqueous phase and an organic phase, separating the aqueous and organic phases and recovering the N-(4-fluorophenyl)-N-(1-methylethyl)-2-[(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)-oxy]-acetamide from the organic phase. A preferred solvent and aqueous alkali are toluene and aqueous sodium hydroxide, respectively.