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1.发明公开NEUE SUBSTITUIERTE BIPYRIDIN-DERIVATE UND IHRE VERWENDUNG ALS ADENOSIN REZEPTOR LIGANDEN 审中-公开新的取代吡啶衍生物及其作为腺苷受体配体
公开(公告)号：EP2066637A1
公开(公告)日：2009-06-10
申请号：EP07801993.2
申请日：2007-08-30
申请人： Bayer HealthCare AG
IPC分类号： C07D213/85 , A61K31/4436 , A61K31/4439 , A61K31/444 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14
CPC分类号： C07D417/14 , A61K31/444 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/85 , C07D401/14 , C07D409/14 , C07D413/14
摘要： The present application relates to novel substituted 2,4'- and 3,4'-bipyridine derivatives according to general formula (I), in which one of the two ring members X and Y represents N and the other ring member represents C-R6. The invention also relates to processes for their preparation, to their use for the treatment and/or prophylaxis of illnesses, and to their use for producing medicaments for the treatment and/or prophylaxis of illnesses, preferably for the treatment and/or prevention of hypertension and other cardiovascular diseases.
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2.发明授权AMINOACYL-PRODRUG DERIVATE UND ARZNEIMITTEL ZUR BEHANDLUNG VON THROMBOEMBOLISCHEN ERKRANKUNGEN 有权氨前体药物衍生物及药物来治疗疾病血栓栓塞
公开(公告)号：EP1987026B1
公开(公告)日：2009-08-26
申请号：EP07703379.3
申请日：2007-02-06
申请人： Bayer HealthCare AG
发明人： LERCHEN, Hans-Georg , KRENZ, Ursula , SCHLEMMER, Karl-Heinz , PERZBORN, Elisabeth , KELDENICH, Joerg
IPC分类号： C07D413/14 , A61P7/02 , A61K31/422
CPC分类号： C07D413/14
摘要： The present application relates to prodrug derivatives of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-morpholin-4-yl)phenyl]-l,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, methods for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolitic disorders.
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3.发明公开BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL IN THE TREATMENT OF CANCERS OF THE CENTRAL NERVOUS SYSTEM 审中-公开苯并呋喃和苯并噻吩衍生物对癌症的中枢神经系统在处理
公开(公告)号：EP2056817A1
公开(公告)日：2009-05-13
申请号：EP07801922.1
申请日：2007-08-28
申请人： Bayer HealthCare AG
发明人： WEBER, Olaf , VOEHRINGER, Verena , LERCHEN, Hans-Georg , HAFNER, Frank-Thorsten , KELDENICH, Joerg , SCHLEMMER, Karl-Heinz , KRENZ, Ursula , RIEDL, Bernd
IPC分类号： A61K31/343 , C07D307/82 , A61P35/00
CPC分类号： A61K31/343 , C07D307/82
摘要： The present invention relates to benzofuran and benzothiophene derivatives and compositions containing such compounds for the production of medicaments for the treatment of cancers of the central nervous system as monotherapy or combination with other agents.
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4.发明公开AMINOACYL-PRODRUG DERIVATE UND ARZNEIMITTEL ZUR BEHANDLUNG VON THROMBOEMBOLISCHEN ERKRANKUNGEN 有权氨前体药物衍生物及药物来治疗疾病血栓栓塞
公开(公告)号：EP1987026A1
公开(公告)日：2008-11-05
申请号：EP07703379.3
申请日：2007-02-06
申请人： Bayer HealthCare AG
发明人： LERCHEN, Hans-Georg , KRENZ, Ursula , SCHLEMMER, Karl-Heinz , PERZBORN, Elisabeth , KELDENICH, Joerg
IPC分类号： C07D413/14 , A61P7/02 , A61K31/422
CPC分类号： C07D413/14
摘要： The present application relates to prodrug derivatives of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-morpholin-4-yl)phenyl]-l,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, methods for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolitic disorders.
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