专利检索 ap:("Bayer HealthCare LLC") AND inv:"APELER, Heiner" 第 1 页

1.

发明公开
MODIFIED FACTOR IX POLYPEPTIDES AND USES THEREOF 审中-公开
标题翻译：修饰的因子IX多肽及其用途

公开(公告)号：EP2461821A1

公开(公告)日：2012-06-13

申请号：EP10805185.5

申请日：2010-08-02

申请人： Bayer HealthCare LLC

发明人： BROOKS, Alan , PATEL, Chandra , JIANG, Xiaoqiao , GRITZAN, Uwe , APELER, Heiner , WANG, Jun

IPC分类号： A61K38/36

CPC分类号： C12N9/644 , A61K38/00 , C12Y304/21022

摘要： The invention relates to modified Factor IX polypeptides such as Factor IX polypeptides with one or more amino acid substitutions. The invention also relates to methods of making modified Factor IX polypeptides, and methods of using modified Factor IX polypeptides, for example, to treat patients afflicted with hemophilia B.

2.

发明公开
METHOD OF DETERMINING PEGYLATED BLOOD COAGULATION FACTOR ACTIVITY IN A SILICA-BASED ACTIVATED PARTIAL THROMBOPLASTIN TIME ASSAY 审中-公开
标题翻译：一种用于确定聚乙二醇化的凝血因子的活性硅基CAPITAL PART-TIME凝血ASSAY

公开(公告)号：EP2368124A1

公开(公告)日：2011-09-28

申请号：EP09828376.5

申请日：2009-11-24

申请人： Bayer HealthCare LLC

发明人： TANG, Liang , APELER, Heiner , RAMSEY, Philip

IPC分类号： G01N33/86

CPC分类号： G01N33/86

摘要： Provided is a method of measuring coagulation activity of a PEGylated blood coagulation factor through a silica based activated partial thromboplastin time (APTT) assay. A PEGylated blood coagulation factor was found to display reduced activity in a silica-based APTT assay, and the addition of PEG to the APTT reaction mixture was shown to restore its activity. Methods for determining the coagulation activity of a PEGylated blood coagulation factor in an APTT assay are provided.