专利检索 ap:("Bayer HealthCare LLC") AND inv:"SZYMANSKI, Paul" 第 1 页

1.

发明公开
DIMERIC MOLECULAR COMPLEXES WITH FREE CYSTEINE RESIDUES AND CONJUGATES THEREOF 审中-公开
标题翻译：有免费的半胱氨酸残基和缀合物二聚体分子复合

公开(公告)号：EP2648751A2

公开(公告)日：2013-10-16

申请号：EP11846369.4

申请日：2011-12-07

申请人： Bayer HealthCare LLC

发明人： LIGHT, David , SZYMANSKI, Paul , SETO, Marian , CORNELIUS, Aline

IPC分类号： A61K39/395 , A61K47/48

CPC分类号： C07K16/00 , A61K51/088 , C07K16/18 , C07K2317/528 , C07K2317/53 , C07K2317/55 , C07K2317/60 , C07K2317/64 , C07K2317/94 , C07K2319/00 , C07K2319/01

摘要： The invention relates generally to dimeric molecular complexes comprising two fusion proteins. Each fusion protein comprises a biological effector moiety, a polypeptide spacer sequence, and an IgE CH4 dimerization domain. The dimeric molecular complexes may be conjugated, at a defined site, to other molecules including drug moieties, cytotoxic agents, labels (such as detectable labels), or biocompatible polymers.