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1.发明授权19-NOR-STEROIDDERIVATE MIT EINER 15ALPHA, 16ALPHA-METHYLENGRUPPE UND EINEM GESÄTTIGTEN 17,17-SPIROLACTONRING, DEREN VERWENDUNG SOWIE DIESE DERIVATE ENTHALTENDE ARZNEIMITTEL 有权WITH A 15ALPHA，16alpha甲基GROUP和饱和17,17-螺内酯，它们的用途和它们的衍生物及药物含19-NOR-甾类衍生物
公开(公告)号：EP2238149B1
公开(公告)日：2015-03-18
申请号：EP08867523.6
申请日：2008-12-23
发明人： KLAR, Ulrich , KUHNKE, Joachim , BOHLMANN, Rolf , HÜBNER, Jan , RING, Sven , FRENZEL, Thomas , MENGES, Frederik , BORDEN, Steffen , MUHN, Hans-Peter , PRELLE, Katja
IPC分类号： C07J53/00 , A61K31/585 , A61P5/34
CPC分类号： C07J21/003 , C07J53/008
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2.发明授权15,16-METHYLEN-17-HYDROXY-19-NOR-21-CARBONSÄURE-STEROID y-LACTON-DERIVAT, DESSEN VERWENDUNG UND DAS DERIVAT ENTHALTENDE ARZNEIMITTEL 有权15,16-亚甲基-17-羟基-19-去甲-21-羧酸-γ-内酯甾类衍生物，它们的用途及药物含有该衍生物的
公开(公告)号：EP2238150B1
公开(公告)日：2012-10-24
申请号：EP08868567.2
申请日：2008-12-23
发明人： KLAR, Ulrich , KUHNKE, Joachim , BOHLMANN, Rolf , HÜBNER, Jan , RING, Sven , FRENZEL, Thomas , MENGES, Frederik , BORDEN, Steffen , MUHN, Hans, Peter , PRELLE, Katja
CPC分类号： C07J53/008
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3.发明授权15,16-METHYLEN-17-(1'-PROPENYL)-17,3'-OXIDOESTRA-4-EN-3-ON-DERIVAT, DESSEN VERWENDUNG UND DAS DERIVAT ENTHALTENDE ARZNEIMITTEL 有权15,16-亚甲基-17-（1'-丙烯基）-17,3'-OXIDOESTRA -4-烯-3-酮衍生物，它们的用途及药物衍生物含
公开(公告)号：EP2238148B1
公开(公告)日：2012-10-24
申请号：EP08866797.7
申请日：2008-12-23
发明人： KLAR, Ulrich , KUHNKE, Joachim , BOHLMANN, Rolf , HÜBNER, Jan , RING, Sven , FRENZEL, Thomas , MENGES, Frederik , BORDEN, Steffen , MUHN, Hans, Peter , PRELLE, Katja
CPC分类号： C07J53/008
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4.发明授权17BETA-CYANO-18A-HOMO-19-NOR-ANDROST-4-EN-DERIVAT, DESSEN VERWENDUNG UND DAS DERIVAT ENTHALTENDE ARZNEIMITTEL 有权17β-氰基18A-HOMO-19-去甲雄甾-4-烯衍生物，其用途及药物含有该衍生物的
公开(公告)号：EP2178899B1
公开(公告)日：2012-10-24
申请号：EP08758989.1
申请日：2008-06-04
发明人： KUHNKE, Joachim , HUEBNER, Jan , BOHLMANN, Rolf , FRENZEL, Thomas , KLAR, Ulrich , MENGES, Frederik , RING, Sven , BORDEN, Steffen , MUHN, Hans-Peter , PRELLE, Katja
CPC分类号： C07J41/0094 , C07J53/007 , C07J53/008
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5.发明公开SPIROINDOLINE DERIVATIVES AS GONADOTROPIN- RELEASING HORMONE RECEPTOR ANTAGONISTS 审中-公开SPIROINDOLIN衍生物作为促性腺激素释放激素受体拮抗剂
公开(公告)号：EP2804867A1
公开(公告)日：2014-11-26
申请号：EP13700304.2
申请日：2013-01-15
发明人： PANKNIN, Olaf , BÄURLE, Stefan , RING, Sven , SCHWEDE, Wolfgang , BONE, Wilhelm , NOWAK-REPPEL, Katrin , BENDER, Eckhard , NUBBEMEYER, Reinhard , GNOTH, Mark, Jean
IPC分类号： C07D491/107 , C07D495/10 , A61K31/4439 , A61K31/407 , A61P5/04 , A61P15/18
CPC分类号： C07D495/10 , C07D491/107
摘要： Spiroindoline derivatives, process for their preparation and pharmaceutical compositions thereof, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially sex-hormone-related diseases in both men and women, in particularly those selded from the group of endometriosis, uterine fibroids, polycystic ovarian disease, hirsutism, precocious puberty, gonadal steroid-dependent neoplasia such as cancers of the prostate, breast and ovary, gonadotrope pituitary adenomas, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hypertrophy, contraception and infertility (e.g., assisted reprodudive therapy such as in vitro fertilization). The present application relates in particular to spiroindoline derivatives as gonadotropin-releasing hormone (GnRH) receptor antagonists.
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6.发明授权17-(1'-PROPENYL)-17-3'-OXIDOESTRA-4-EN-3-ON-DERIVAT, DESSEN VERWENDUNG UND DAS DERIVAT ENTHALTENDE ARZNEIMITTEL 有权17-（1'-丙烯基）-17-3'-OXIDOESTRA -4-烯-3-酮衍生物，它们的用途及药物衍生物含
公开(公告)号：EP2238147B1
公开(公告)日：2012-10-24
申请号：EP08867342.1
申请日：2008-12-23
发明人： KLAR, Ulrich , KUHNKE, Joachim , BOHLMANN, Rolf , HÜBNER, Jan , RING, Sven , FRENZEL, Thomas , MENGES, Frederik , BORDEN, Steffen , MUHN, Hans, Peter , PRELLE, Katja
CPC分类号： C07J21/00 , C07J41/0016 , C07J53/001 , C07J53/007
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