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公开(公告)号：EP2699554A1
公开(公告)日：2014-02-26
申请号：EP12714336.0
申请日：2012-04-18
发明人： LÜCKING, Ulrich , BOHLMANN, Rolf , SCHOLZ, Arne , SIEMEISTER, Gerhard , GNOTH, Mark, Jean , BÖMER, Ulf , RÜHTER, Gerd , SCHULZ-FADEMRECHT, Carsten , KOSEMUND, Dirk , LIENAU, Philip
IPC分类号： C07D251/12 , C07D401/04 , C07D405/10 , C07D405/12 , A61K31/497 , A61P35/00
CPC分类号： C07D251/42 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12
摘要： The present invention relates to substituted 4-Aryl-N-phenyl-1,3,5-triazin-2-amines of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
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公开(公告)号：EP2699554B1
公开(公告)日：2016-11-02
申请号：EP12714336.0
申请日：2012-04-18
发明人： LÜCKING, Ulrich , BOHLMANN, Rolf , SCHOLZ, Arne , SIEMEISTER, Gerhard , GNOTH, Mark, Jean , BÖMER, Ulf , RÜHTER, Gerd , SCHULZ-FADEMRECHT, Carsten , KOSEMUND, Dirk , LIENAU, Philip
IPC分类号： C07D401/12 , C07D405/04 , C07D251/42 , C07D401/04 , C07D405/12
CPC分类号： C07D251/42 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12
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3.发明授权SULFONSUBSTITUIERTE ANLINOPYRIMIDINDERIVATIVE ALS CDK-INHIBITOREN, DEREN HERSTELLUNG UND VERWENDUNG ALS ARZNEIMITTEL 有权SULFONSUBSTITUIERTE ANLINOPYRIMIDINDERIVATIVE作为CDK抑制剂的，生产与应用，药物
公开(公告)号：EP2342185B1
公开(公告)日：2016-01-13
申请号：EP09778863.2
申请日：2009-10-08
IPC分类号： C07D239/47 , A61K31/505 , A61P35/00
CPC分类号： C07D239/47
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4.发明授权DISUBSTITUTED 5-FLUORO PYRIMIDINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP 有权WITH A亚磺酰亚胺二取代5- FLUOR-嘧啶衍生物
公开(公告)号：EP2755948B1
公开(公告)日：2016-05-25
申请号：EP12758496.9
申请日：2012-09-13
发明人： LÜCKING, Ulrich , KOSEMUND, Dirk , SCHOLZ, Arne , LIENAU, Philip , SIEMEISTER, Gerhard , BÖMER, Ulf , BOHLMANN, Rolf
IPC分类号： C07C381/10 , C07D239/42 , C07D405/04 , A61K31/505 , A61P9/00 , A61P31/12 , A61P35/00
CPC分类号： C07D405/04 , A61K31/505 , A61K31/506 , C07C381/10 , C07D239/42
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公开(公告)号：EP2550257B1
公开(公告)日：2016-12-21
申请号：EP11711039.5
申请日：2011-03-20
发明人： EICKHOFF, Jan , NUSSBAUMER, Peter , RÜHTER, Gerd , SCHULTZ-FADEMRECHT, Carsten , LÜCKING, Ulrich , CHOIDAS, Axel , KLEBL, Bert
IPC分类号： C07D251/22 , C07D401/04 , C07D403/12 , C07D407/04 , A61K31/53 , A61P35/00 , A61P37/00 , C07D401/12
CPC分类号： C07D251/16 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D251/22 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/10 , C07D407/04 , C07D413/10
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6.发明授权
公开(公告)号：EP2755956B1
公开(公告)日：2016-05-18
申请号：EP12761590.4
申请日：2012-09-13
发明人： LÜCKING, Ulrich , KOSEMUND, Dirk , SCHOLZ, Arne , LIENAU, Philip , SIEMEISTER, Gerhard , BÖMER, Ulf , BOHLMANN, Rolf
IPC分类号： C07D239/42 , C07D407/04 , A61K31/505 , A61K31/506 , A61P35/00 , C07D401/12
CPC分类号： C07D239/42 , A61K31/505 , A61K31/506 , C07D401/12 , C07D405/04 , C07D407/04
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公开(公告)号：EP2755956A1
公开(公告)日：2014-07-23
申请号：EP12761590.4
申请日：2012-09-13
发明人： LÜCKING, Ulrich , KOSEMUND, Dirk , SCHOLZ, Arne , LIENAU, Philip , SIEMEISTER, Gerhard , BÖMER, Ulf , BOHLMANN, Rolf
IPC分类号： C07D239/42 , C07D407/04 , A61K31/505 , A61K31/506 , A61P35/00 , C07D401/12
CPC分类号： C07D239/42 , A61K31/505 , A61K31/506 , C07D401/12 , C07D405/04 , C07D407/04
摘要： The present invention relates to disubstituted 5-fluoro-pyrimidines of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
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8.发明授权4-Aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group 有权具有磺基肟4-芳基-N-苯基-1,3,5-三嗪-2-胺
公开(公告)号：EP2714654B1
公开(公告)日：2015-07-22
申请号：EP12721558.0
申请日：2012-05-21
发明人： LÜCKING, Ulrich , BOHLMANN, Rolf , SCHOLZ, Arne , SIEMEISTER, Gerhard , GNOTH, Mark, Jean , BÖMER, Ulf , KOSEMUND, Dirk , LIENAU, Philip , RÜHTER, Gerd , SCHULZ-FADEMRECHT, Carsten
IPC分类号： C07C311/13 , C07D251/16 , C07D251/22 , A61K31/53 , A61P9/00 , A61P31/00 , C07D401/12 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/12
CPC分类号： A61K31/53 , C07B59/002 , C07B2200/05 , C07C381/10 , C07D251/16 , C07D251/22 , C07D251/42 , C07D251/44 , C07D401/12 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/12
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9.发明授权SULFOXIMINSUBSTITUIERTE ANILINOPYRIMIDINDERATIVE ALS CDK-INHIBITOREN, DEREN HERSTELLUNG UND VERWENDUNG ALS ARZEINMITTEL 有权磺胺嘧啶取代的苯胺基吡啶作为CDK抑制剂，它们的制备和用作药物
公开(公告)号：EP2350026B1
公开(公告)日：2014-06-18
申请号：EP09778874.9
申请日：2009-10-09
IPC分类号： C07D239/47 , A61K31/505 , A61P35/00
CPC分类号： C07D239/47
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公开(公告)号：EP2550257A1
公开(公告)日：2013-01-30
申请号：EP11711039.5
申请日：2011-03-20
发明人： EICKHOFF, Jan , NUSSBAUMER, Peter , RÜHTER, Gerd , SCHULTZ-FADEMRECHT, Carsten , LÜCKING, Ulrich , CHOIDAS, Axel , KLEBL, Bert
IPC分类号： C07D251/22 , C07D401/04 , C07D403/12 , C07D407/04 , A61K31/53 , A61P35/00 , A61P37/00 , C07D401/12
CPC分类号： C07D251/16 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D251/22 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/10 , C07D407/04 , C07D413/10
摘要： The present invention relates to disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said disubstituted triazine derivatives as inhibitors for a protein kinase. formula (I) wherein R
1 is formula (II), formula (III) or formula (IV).摘要翻译： 本发明涉及二取代的三嗪衍生物和/或其药学上可接受的盐，这些衍生物作为药物活性剂的用途，特别是用于预防和/或治疗感染性疾病，包括机会性疾病，免疫疾病，自身免疫性疾病，心血管疾病 ，细胞增殖性疾病，炎症，勃起功能障碍和中风，以及含有所述二取代的三嗪衍生物和/或其药学上可接受的盐中的至少一种的药物组合物。 此外，本发明涉及所述二取代三嗪衍生物作为蛋白激酶的抑制剂的用途。
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