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公开(公告)号：EP2802588A1
公开(公告)日：2014-11-19
申请号：EP13700987.4
申请日：2013-01-08
发明人： BÄRFACKER, Lars , SCOTT, William , HÄGEBARTH, Andreas , REHWINKEL, Hartmut , POLITZ, Oliver , NEUHAUS, Roland , BÖMER, Ulf
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： A61K31/519 , A61K45/06 , C07D487/04
摘要： Compounds of formula (I) which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
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公开(公告)号：EP2802588B1
公开(公告)日：2016-05-25
申请号：EP13700987.4
申请日：2013-01-08
发明人： BÄRFACKER, Lars , SCOTT, William , HÄGEBARTH, Andreas , REHWINKEL, Hartmut , POLITZ, Oliver , NEUHAUS, Roland , BÖMER, Ulf
IPC分类号： A61K45/06
CPC分类号： A61K31/519 , A61K45/06 , C07D487/04
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公开(公告)号：EP2802586B1
公开(公告)日：2016-05-25
申请号：EP13700139.2
申请日：2013-01-08
发明人： BÄRFACKER, Lars , SCOTT, William , HÄGEBARTH, Andrea , INCE, Stuart , REHWINKEL, Hartmut , POLITZ, Oliver , NEUHAUS, Roland , BÖMER, Ulf
IPC分类号： A61K45/06
CPC分类号： C07D487/04 , A61K31/4985 , A61K45/06 , A61K2300/00
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公开(公告)号：EP2802586A1
公开(公告)日：2014-11-19
申请号：EP13700139.2
申请日：2013-01-08
发明人： BÄRFACKER, Lars , SCOTT, William , HÄGEBARTH, Andrea , INCE, Stuart , REHWINKEL, Hartmut , POLITZ, Oliver , NEUHAUS, Roland , BÖMER, Ulf
IPC分类号： C07D487/04 , A61K31/4985 , A61P35/00
CPC分类号： C07D487/04 , A61K31/4985 , A61K45/06 , A61K2300/00
摘要： Compounds of formula (I) which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
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公开(公告)号：EP2576560A1
公开(公告)日：2013-04-10
申请号：EP11725886.3
申请日：2011-05-27
发明人： KLAR, Ulrich , KOPPITZ, Marcus , JAUTELAT, Rolf , KOSEMUND, Dirk , BOHLMANN, Rolf , BADER, Benjamin , LIENAU, Philip , SIEMEISTER, Gerhard , SCOTT, William
IPC分类号： C07D487/04 , A61K31/4985
CPC分类号： C07D487/04 , A61K31/4985
摘要： The present invention relates to substituted imidazopyrazine compounds of general formula (I) in which A, R
1 , R
3 and R
5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.-
6.发明公开6H-THIENO[3,2-f][1,2,4]TRIAZOLO[4,3-a][1,4]DIAZEPINE 审中-公开-6H-噻吩并[3,2-f]的[1,2,4]三唑并[4,3-α] [1,4]二氮杂
公开(公告)号：EP2751114A1
公开(公告)日：2014-07-09
申请号：EP12766291.4
申请日：2012-08-27
发明人： SCHMEES, Norbert , KUHNKE, Joachim , HAENDLER, Bernard , LIENAU, Philip , FERNANDEZ-MONTALVAN, Amaury, Ernesto , LEJEUNE, Pascale , SIEGEL, Stephan , SCOTT, William
IPC分类号： C07D495/14 , A61K31/5517 , A61P35/00 , A61P29/00
CPC分类号： C07D519/00 , A61K31/551 , A61K45/06 , C07D495/14 , A61K2300/00
摘要： The invention relates to
6H -thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepines, in particular for therapeutic purposes, to pharmaceutical agents, and to the use thereof in treatment, in particular for the prophylaxis and treatment of tumor diseases.-
公开(公告)号：EP2547680A1
公开(公告)日：2013-01-23
申请号：EP11708301.4
申请日：2011-03-16
发明人： KLAR, Ulrich , KOPPITZ, Marcus , KOSEMUND, Dirk , BOHLMANN, Rolf , BADER, Benjamin , LIENAU, Philip , SIEMEISTER, Gerhard , PRECHTL, Stefan , NGUYEN, Duy , SCOTT, William
IPC分类号： C07D487/04 , A61K31/4985 , A61P35/00
CPC分类号： A61K31/519 , A61K45/06 , C07D487/04 , C07D487/14
摘要： The present invention relates to imidazopyrazine compounds of general Formula (I) : in which X, R
1 , R
2 , R
3a , R
3b , R
4a , R
4b , R
4C , and R
4D are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.-
8.发明授权SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS 有权取代的2,3-二氢[1,2-C]喹唑啉衍生物，其用于治疗过度增生性疾病和血管形成有关的疾病中，合适于治疗
公开(公告)号：EP2096919B1
公开(公告)日：2016-03-02
申请号：EP07862580.3
申请日：2007-12-05
发明人： HENTEMANN, Martin , WOOD, Jill , SCOTT, William , MICHELS, Martin , CAMPBELL, Ann-Marie , BULLION, Ann-Marie , ROWLEY, R. Bruce , REDMAN, Aniko
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5377
CPC分类号： A61K31/5377 , A01N43/90 , A61K31/519 , C07D487/04
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公开(公告)号：EP2547680B1
公开(公告)日：2015-08-05
申请号：EP11708301.4
申请日：2011-03-16
发明人： KLAR, Ulrich , KOPPITZ, Marcus , KOSEMUND, Dirk , BOHLMANN, Rolf , BADER, Benjamin , LIENAU, Philip , SIEMEISTER, Gerhard , PRECHTL, Stefan , NGUYEN, Duy , SCOTT, William
IPC分类号： C07D487/04 , A61K31/4985 , A61P35/00
CPC分类号： A61K31/519 , A61K45/06 , C07D487/04 , C07D487/14
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公开(公告)号：EP2576560B1
公开(公告)日：2015-09-30
申请号：EP11725886.3
申请日：2011-05-27
发明人： KLAR, Ulrich , KOPPITZ, Marcus , JAUTELAT, Rolf , KOSEMUND, Dirk , BOHLMANN, Rolf , BADER, Benjamin , LIENAU, Philip , SIEMEISTER, Gerhard , SCOTT, William
IPC分类号： C07D487/04 , A61K31/4985
CPC分类号： C07D487/04 , A61K31/4985
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