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公开(公告)号：EP3215493B1
公开(公告)日：2019-01-23
申请号：EP15790150.5
申请日：2015-11-05
发明人： PETERS, Jan-Georg , RUBENBAUER, Philipp , GÖTZ, Daniel , GROßBACH, Danja , MAIS, Franz-Josef , SCHIRMER, Heiko , STIEHL, Juergen , LOVIS, Kai , LENDER, Andreas , SEYFRIED, Martin , ZWEIFEL, Theodor , MARTY, Maurus , WEINGÄRTNER, Günter
IPC分类号： C07D233/24 , C07D487/04
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2.发明公开METHOD FOR PREPARING SUBSTITUTED TRIAZOLOPYRIDINES 审中-公开VERFAHREN ZUR HERSTELLUNG SUBSTITUERTER TRIAZOLOPYRIDINE
公开(公告)号：EP2872506A1
公开(公告)日：2015-05-20
申请号：EP13737181.1
申请日：2013-07-03
发明人： SCHULZE, Volker , MAIS, Franz-Josef
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04
摘要： The present invention relates to methods of preparing substituted triazolopyridine compounds of general formula (I) as described and defined herein, as well as to intermediate compounds useful in the preparation of said compounds.
摘要翻译： 本发明涉及制备本文所述和定义的通式（I）的取代三唑并吡啶化合物的方法，以及可用于制备所述化合物的中间体化合物。
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公开(公告)号：EP3215493A2
公开(公告)日：2017-09-13
申请号：EP15790150.5
申请日：2015-11-05
发明人： PETERS, Jan-Georg , RUBENBAUER, Philipp , GÖTZ, Daniel , GROßBACH, Danja , MAIS, Franz-Josef , SCHIRMER, Heiko , STIEHL, Juergen , LOVIS, Kai , LENDER, Andreas , SEYFRIED, Martin , ZWEIFEL, Theodor , MARTY, Maurus , WEINGÄRTNER, Günter
IPC分类号： C07D233/24 , C07D487/04
CPC分类号： C07D487/04 , C07D233/24
摘要： The present invention relates to a novel method of preparing copanlisib, and copanlisib dihydrochloride, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said copanlisib.
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4.发明公开MODIFIKATION I DER 4-({4-CARBOXYBUTYL)Ý2-(2-{Ý4-(2-PHENYLETHYL)BENZYL¨OXY}PHENYL)ETHYL¨-AMINO}METHYL)BENZOESÄURE 审中-公开（{4-羧基丁基）的Y2（2- {Y4（2-苯乙基）苄基氧基}苯基）乙基] - 氨基}甲基）苯甲酸 - 4的变体I
公开(公告)号：EP2379489A1
公开(公告)日：2011-10-26
申请号：EP09774834.7
申请日：2009-12-04
IPC分类号： C07C229/38 , A61K31/197 , A61P9/00
CPC分类号： C07C229/38
摘要： The invention relates to novel forms of 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid, especially modification I, methods for the production thereof, medicaments containing the same, and the use thereof for fighting diseases.
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公开(公告)号：EP3292133B1
公开(公告)日：2019-06-26
申请号：EP16722584.6
申请日：2016-05-02
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6.发明公开VERFAHREN ZUR HERSTELLUNG VON 2-{4-[2-({[2-(4-CHLORPHENYL)-1,3-THIAZOL-4-YL]METHYL}SULFANYL)-3,5-DICYAN-6-(PYRROLIDIN-1-YL)PYRIDIN-4-YL]PHENOXY}ETHYL-L-ALANYL-L-ALANINAT-MONOHYDROCHLORID 有权实施例2 2- {4- [2 - （{[2-（4-氯苯基）-1,3-噻唑-4-基]甲基}磺酰基）-3,5-二嗪-6-（吡咯烷-1 基）吡啶-4-基]苯氧基}乙基-L-丙氨酰-L-ALANINAT-MONOHYDROCHLORID
公开(公告)号：EP3292133A1
公开(公告)日：2018-03-14
申请号：EP16722584.6
申请日：2016-05-02
发明人： MAIS, Franz-Josef , HEILMANN, Werner , OLENIK, Britta , KEIL, Birgit , BECKER, Guido , MEIBOM, Daniel , KUHLMANN, Thomas
CPC分类号： C07D417/12 , A61K47/64 , C07K5/06026
摘要： The present invention relates to a novel and improved process for the preparation of the compound 2-{4-[2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)-pyridin-4-yl]-phenoxy}-ethyl-L-alanyl-L-alaninate monohydrochloride of formula (I), new precursors for their preparation, as well as to the production and use of the crystalline modification I of 2-{4-[2-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-3,5-dicyano-6-(pyrrolidin-1-yl)pyridin-4-yl]phenoxy}ethyl-L-alanyl-L-alaninate monohydrochloride of formula (I).
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7.发明公开MONOHYDRAT DER 4-({(4-CARBOXYBUTYL)[2-(2-{[4-(2-PHENYLETHYL)BENZYL]OXY}PHENYL)ETHYL]-AMINO}METHYL)BENZOESÄURE 审中-公开MONOHYDRAT DER 4 - （{（4-羧基丁基）[2-（2 - {[4-（2-苯基乙基）苄基]氧基}苯基）乙基] - 氨基}甲基）苯甲酸
公开(公告)号：EP2379490A1
公开(公告)日：2011-10-26
申请号：EP09774838.8
申请日：2009-12-08
IPC分类号： C07C229/38 , A61K31/197 , A61P9/00
CPC分类号： C07C229/38
摘要： The invention relates to novel forms of 4-({(4-carboxybutyl)[2-(2-{[4-(2- phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid, especially the monohydrate in form A, methods for the production thereof, medicaments containing the same, and the use thereof for fighting diseases.
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