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1.发明授权DISUBSTITUTED BENZOTHIENYL-PYRROLOTRIAZINES AND THEIR USE AS FGFR KINASE INHIBITORS 有权二取代噻吩基吡咯并三及其作为FGFR激酶抑制剂
公开(公告)号：EP2791140B1
公开(公告)日：2016-06-15
申请号：EP12798738.6
申请日：2012-12-10
发明人： BROHM, Dirk , HEROULT, Melanie , COLLIN, Marie-Pierre , HÜBSCH, Walter , LOBELL, Mario , LUSTIG, Klemens , GRÜNEWALD, Sylvia , BÖMER, Ulf , VÖHRINGER, Verena
IPC分类号： C07D487/04 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5355 , A61K31/5377 , A61K31/541
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2.发明授权HYDROXYMETHYLARYL-SUBSTITUTED PYRROLOTRIAZINES AS ALK1 INHIBITORS 有权HYDROXYMETHYLARYL-取代的吡咯并三ALK1抑制剂
公开(公告)号：EP2726482B1
公开(公告)日：2016-07-20
申请号：EP12730515.9
申请日：2012-06-26
发明人： KLAR, Jürgen , VOEHRINGER, Verena , TELSER, Joachim , LOBELL, Mario , SÜßMEIER, Frank , LI, Volkhart Min-Jian , BÖTTGER, Michael , GOLZ, Stefan , LANG, Dieter , SCHLEMMER, Karl-Heinz , SCHLANGE, Thomas , SCHALL, Andreas , FU, Wenlang
IPC分类号： C07D487/04 , A61K31/53 , A61P27/00
CPC分类号： A61K31/5377 , A61K31/4427 , A61K31/53 , C07D401/04 , C07D487/04
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3.发明公开DISUBSTITUTED BENZOTHIENYL-PYRROLOTRIAZINES AND THEIR USE AS FGFR KINASE INHIBITORS 有权二取代噻吩基吡咯并三及其作为FGFR激酶抑制剂
公开(公告)号：EP2791140A1
公开(公告)日：2014-10-22
申请号：EP12798738.6
申请日：2012-12-10
发明人： BROHM, Dirk , HEROULT, Melanie , COLLIN, Marie-Pierre , HÜBSCH, Walter , LOBELL, Mario , LUSTIG, Klemens , GRÜNEWALD, Sylvia , BÖMER, Ulf , VÖHRINGER, Verena
IPC分类号： C07D487/04 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5355 , A61K31/5377 , A61K31/541
摘要： This invention relates to novel substituted 5-(1-benzothiophen-2-yl) pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives of formula (I) wherein R
1 is hydrogen, chloro, methyl or methoxy, R
2 is hydrogen or methoxy, with the proviso that at least one of R
1 and R
2 is other than hydrogen, G
1 represents chloro, (C
1 -C
4 )-alkyl, (C
1 -C
4 )-alkoxycarbonyl, 5-membered aza-heteroaryl, or the group -CH
2 -OR
3 , -CH
2 -NR
4 R
5 or -C(=0)- NR
4 R
6 , and G
2 represents chloro, cyano, (C
1 -C
4 )-alkyl, or the group - CR
8A R
8B -OH, -CH
2 -NR
9 R
10 , -C(=0)-NR
11 R
12 or -CH
2 -OR
15 , having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.-
4.发明公开HYDROXYMETHYLARYL-SUBSTITUTED PYRROLOTRIAZINES AS ALK1 INHIBITORS 有权HYDROXYMETHYLARYL-取代的吡咯并三ALK1抑制剂
公开(公告)号：EP2726482A1
公开(公告)日：2014-05-07
申请号：EP12730515.9
申请日：2012-06-26
发明人： KLAR, Jürgen , VOEHRINGER, Verena , TELSER, Joachim , LOBELL, Mario , SÜßMEIER, Frank , LI, Volkhart Min-Jian , BÖTTGER, Michael , GOLZ, Stefan , LANG, Dieter , SCHLEMMER, Karl-Heinz , SCHLANGE, Thomas , SCHALL, Andreas , FU, Wenlang
IPC分类号： C07D487/04 , A61K31/53 , A61P27/00
CPC分类号： A61K31/5377 , A61K31/4427 , A61K31/53 , C07D401/04 , C07D487/04
摘要： This invention relates to novel 5-[(hydroxymethyl)aryl] -substituted pyrrolo[2, 1-f][1, 2, 4] triazin-4-amines of formula (I), to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating angiogenesis-related disorders, in particular angiogenesis-related ocular disorders.
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公开(公告)号：EP2807162B1
公开(公告)日：2017-06-07
申请号：EP13700765.4
申请日：2013-01-22
发明人： SÜßMEIER, Frank , LOBELL, Mario , GRÜNEWALD, Sylvia , HÄRTER, Michael , BUCHMANN, Bernd , TELSER, Joachim , JÖRIßEN, Hannah , HÉROULT, Mélanie , KAHNERT, Antje , LUSTIG, Klemens , LINDNER, Niels
IPC分类号： C07D487/04 , A61K31/4188 , A61P35/00
CPC分类号： C07D487/04 , A61K31/4188 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K45/06
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6.发明授权
公开(公告)号：EP2791143B1
公开(公告)日：2016-02-24
申请号：EP12809680.7
申请日：2012-12-11
发明人： COLLIN, Marie-Pierre , BROHM, Dirk , HÉROULT, Mélanie , LOBELL, Mario , HÜBSCH, Walter , LUSTIG, Klemens , GRÜNEWALD, Sylvia , BÖMER, Ulf , VÖHRINGER, Verena , LINDNER, Niels
IPC分类号： C07D487/04 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/553 , C07D409/04 , C07D409/14
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公开(公告)号：EP2807162A1
公开(公告)日：2014-12-03
申请号：EP13700765.4
申请日：2013-01-22
发明人： SÜßMEIER, Frank , LOBELL, Mario , GRÜNEWALD, Sylvia , HÄRTER, Michael , BUCHMANN, Bernd , TELSER, Joachim , JÖRIßEN, Hannah , HEROULT, Melanie , KAHNERT, Antje , LUSTIG, Klemens , LINDNER, Niels
IPC分类号： C07D487/04 , A61K31/4188 , A61P35/00
CPC分类号： C07D487/04 , A61K31/4188 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K45/06
摘要： The present application relates to novel 1-phenyl-1
H -imidazo[1,2-b]pyrazole derivatives of the fomula (I), to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially of angiogenic disorders and hyperproliferative disorders where neovascularization is involved, for example cancers and tumors. Such treatments can be effected as a monotherapy or else in combination with other medicaments or further therapeutic measures.-
8.发明公开
公开(公告)号：EP2791143A1
公开(公告)日：2014-10-22
申请号：EP12809680.7
申请日：2012-12-11
发明人： COLLIN, Marie-Pierre , BROHM, Dirk , HÉROULT, Mélanie , LOBELL, Mario , HÜBSCH, Walter , LUSTIG, Klemens , GRÜNEWALD, Sylvia , BÖMER, Ulf , VÖHRINGER, Verena , LINDNER, Niels
IPC分类号： C07D487/04 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/553 , C07D409/04 , C07D409/14
摘要： This invention relates to novel substituted 5-(l-benzothiophen-2-yl)pyrrolo[2,l-fJ[l,2,4]triazin-4-amine derivatives having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.
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9.发明授权BI- AND TRICYCLIC INDAZOLE-SUBSTITUTED 1,4-DIHYDROPYRIDINE DERIVATIVES AND USES THEREOF 有权二和三环INDAZOLSUBSTITUIERTE 1,4-二氢吡啶衍生物及其应用
公开(公告)号：EP2398790B1
公开(公告)日：2013-07-03
申请号：EP10702634.6
申请日：2010-02-05
发明人： MICHELS, Martin , FOLLMANN, Markus , VAKALOPOULOS, Alexandros , ZIMMERMANN, Katja , LOBELL, Mario , TEUSCH, Nicole , YUAN, Shendong
IPC分类号： C07D401/04 , C07D471/04 , C07D491/048 , C07D491/052 , C07D491/147 , C07D491/153 , C07D495/04 , A61K31/4353 , A61K31/4355 , A61K31/436 , A61K31/437 , A61K31/438 , A61K31/4427 , A61P35/00
CPC分类号： C07D491/048 , C07D401/04 , C07D471/04 , C07D491/052 , C07D491/147 , C07D491/153 , C07D495/04 , C07D498/14
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10.发明授权FLUORO-SUBSTITUTED 2-ARYL-3,5-DICYANO-4-INDAZOLYL-6-METHYL-1,4-DIHYDROPYRIDINES AND USES THEREOF 有权FLUOR取代的2-芳基-3,5-二氰基-4-吲唑基-6-甲基-1,4-二氢吡啶及其用途
公开(公告)号：EP2499124B1
公开(公告)日：2015-08-19
申请号：EP10775812.0
申请日：2010-11-08
发明人： VAKALOPOULOS, Alexandros , MICHELS, Martin , ZIMMERMANN, Katja , TEUSCH, Nicole , LOBELL, Mario , ENGEL, Karen
IPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , A61K31/4439 , A61P35/00
CPC分类号： C07D413/14 , C07D401/04 , C07D401/14
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