公开(公告)号：EP1580188A1

公开(公告)日：2005-09-28

申请号：EP05007027.5

申请日：2003-02-11

申请人： Bayer Pharmaceuticals Corporation

发明人： Dumas, Jacques ,  Scott, William J. ,  Chien, Du-Schieng ,  Lee, Wendy ,  Bjorge, Susan ,  Musza, Laszlo ,  Nassar, Ala ,  Riedl, Bernd

IPC分类号： C07D213/79 ,  C07D213/81 ,  C07D213/89 ,  A61K31/44 ,  A61P11/00 ,  A61P19/00 ,  A61P25/00 ,  A61P29/00

CPC分类号： C07D213/79 ,  C07D213/81 ,  C07D213/89

摘要： This invention relates to new aryl ureas of formula (I) and methods for their synthesis. The compounds are useful in the treatment of (i) raf mediated diseases, for example, cancer, (ii) p38 mediated diseases such as inflammation and osteoporosis, and (iii) VEGF mediated diseases such as angiogenesis disorders.