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公开(公告)号:EP2221620A2
公开(公告)日:2010-08-25
申请号:EP10164475.5
申请日:2003-08-11
发明人: Yalkinoglu, Oezkan, Dr. , König, Gerhard, Dr. , Hochstrasser, Denis Francois, Prof.Dr. , Sanchez, Jean-Charles, Dr. , Carette, Odile, Dr.
IPC分类号: G01N33/68
CPC分类号: G01N33/6896 , C07K14/70539 , C07K14/805 , C07K14/8139 , G01N2800/2821
摘要: A method for assessing the state of Alzheimer's disease in patients is disclosed. A method for monitoring the progression of Alzheimer's disease in patients is also disclosed. The method applies detection of specific markers in body fluids (e.g. CSF), using mass spectrometric analysis (SELDI-TOF MS). The specific markers are: human cystatin C, human beta-2-microglobulin, human myoglobin neurosecretory protein VGF or fragments of these proteins.
摘要翻译: 公开了一种评估患者中阿尔茨海默病状态的方法。 还公开了一种监测患者中阿尔茨海默病进展的方法。 该方法使用质谱分析(SELDI-TOF MS)应用体液(例如CSF)中特定标志物的检测。 具体的标记物是:人半胱氨酸蛋白酶抑制剂C,人β-2-微球蛋白,人肌红蛋白神经分泌蛋白VGF或这些蛋白质的片段。
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公开(公告)号:EP2221620A3
公开(公告)日:2010-11-24
申请号:EP10164475.5
申请日:2003-08-11
发明人: Yalkinoglu, Oezkan, Dr. , König, Gerhard, Dr. , Hochstrasser, Denis Francois, Prof.Dr. , Sanchez, Jean-Charles, Dr. , Carette, Odile, Dr.
IPC分类号: G01N33/68
CPC分类号: G01N33/6896 , C07K14/70539 , C07K14/805 , C07K14/8139 , G01N2800/2821
摘要: A method for assessing the state of Alzheimer's disease in patients is disclosed. A method for monitoring the progression of Alzheimer's disease in patients is also disclosed. The method applies detection of specific markers in body fluids (e.g. CSF), using mass spectrometric analysis (SELDI-TOF MS). The specific markers are: human cystatin C, human beta-2-microglobulin, human myoglobin neurosecretory protein VGF or fragments of these proteins.
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