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1.发明公开ESTRATRIENE DERIVATIVES COMPRISING HETEROCYCLIC BIOISOSTERES FOR THE PHENOLIC A-RING 审中-公开随着对酚A环的杂环生物电子等排雌三烯衍生物
公开(公告)号：EP2307439A1
公开(公告)日：2011-04-13
申请号：EP09800008.6
申请日：2009-07-14
发明人： BLUME, Thorsten , HELDMANN, Dieter , SCHMEES, Norbert , OTTO, Christiane , WINTERMANTEL, Tim , KUHNKE, Joachim
CPC分类号： C07J71/0047
摘要： The present invention is directed to novel pyrazolo-estrien and triazolo-estrien-derivatives, pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases mediated by an estrogen receptor such as hot flashes, vaginal dryness, osteopenia, osteoporosis, hyperlipidemia, loss of cognitive function, degenerative brain diseases, cardiovascular diseases, cerebrovascular diseases, hormone sensitive cancers and hyperplasia (in tissues including breast, endometrium, and cervix in women and prostate in men), endometriosis, uterine fibroids, osteoarthritis; and as contraceptive agents either alone or in combination with a progestogen or progestogen antagonist. The compounds of the invention are selective estrogen receptor modulators.
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