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公开(公告)号：EP4149974A1
公开(公告)日：2023-03-22
申请号：EP21723767.6
申请日：2021-05-11
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Université Paris-Est Créteil Val de Marne , Baylor Research Institute , ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
发明人： LEVY, Yves , ZURAWSKI, Sandra , ZURAWSKI, Gérard
IPC分类号： C07K16/28 , C07K14/705 , A61P35/00
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公开(公告)号：EP2892561A1
公开(公告)日：2015-07-15
申请号：EP13835251.3
申请日：2013-09-06
申请人： Baylor Research Institute , Institut National de la Santé et de la Recherche Médicale (INSERM) , Agence Nationale De Recherches Sur Le Sida Et Les Hepatitis
IPC分类号： A61K39/395 , A61P31/18 , A61P31/00
CPC分类号： C07K16/2851 , A61K39/12 , A61K2039/505 , A61K2039/55555 , A61K2039/55561 , A61K2039/6056 , A61K2039/62 , C07K16/28 , C07K16/2878 , C07K2319/33 , C12N2740/16134
摘要： Embodiments relate methods and composition involving an HIV vaccine comprising an anti-LOX-1 antibody or a fragment thereof to which at least one HIV antigen is attached to form an antibody-antigen fusion protein (Ab.Ag) or an antibody-antigen complex (Ab:Ag). Embodiments also concern methods and compositions involving a combined HIV vaccine comprising a first HIV vaccine according as described above and a second HIV vaccine.
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公开(公告)号：EP4061835A1
公开(公告)日：2022-09-28
申请号：EP20807776.8
申请日：2020-11-20
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Assistance Publique-Hôpitaux de Paris (APHP) , Université Paris-Est Créteil Val de Marne , Baylor Research Institute , Mabquest
发明人： LEVY, Yves , PANTALEO, Giuseppe , FENWICK, Craig , ZURAWSKI, Sandra , ZURAWSKI, Gérard , SEDDIKI, Nabila
IPC分类号： C07K14/54 , C07K14/715 , C07K16/28
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公开(公告)号：EP2688592A1
公开(公告)日：2014-01-29
申请号：EP12765865.6
申请日：2012-03-26
IPC分类号： A61K39/395 , A61P31/12 , C07K16/46 , A61K39/29 , A61P37/04 , C12N5/0784
CPC分类号： C12N5/0639 , A61K39/12 , A61K39/29 , A61K2039/6056 , C07K14/005 , C07K16/2851 , C07K16/2878 , C07K2319/00 , C07K2319/33 , C12N2770/24222 , C12N2770/24234
摘要： Compositions comprising viral antigens and antigenic peptides corresponding to or derived from Hepatitis C virus (HCV) proteins or fragments thereof, fused to heavy and/or light chain of antibodies, or fragments thereof specific for dendritic cells (DCs) are described herein. Included herein are immunostimulatory compositions (HCV vaccines, HCV antigen presenting dendritic cells, etc.) and methods for increasing effectiveness of HCV antigen presentation by an antigen presenting cell, for a treatment, a prophylaxis or a combination thereof against hepatitis C in a human subject, and methods of providing immunostimulation by activation of one or more dendritic cells, methods to treat or prevent hepatitis C.
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公开(公告)号：EP3891506A1
公开(公告)日：2021-10-13
申请号：EP19813034.6
申请日：2019-12-06
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Université Paris-Est Créteil Val de Marne , Assistance Publique-Hôpitaux de Paris (APHP) , Hopital Foch , Université de Versailles Saint-Quentin-en-Yvelines
IPC分类号： G01N33/68
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公开(公告)号：EP2846818A1
公开(公告)日：2015-03-18
申请号：EP13721727.9
申请日：2013-05-07
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Université Paris-Est Créteil Val de Marne , Assistance Publique-Hôpitaux de Paris
发明人： LEVY, Yves , HÜE, Sophie
CPC分类号： A61K39/0008 , A61K38/1709 , A61K38/177 , A61K45/06 , C07K14/705 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/505 , G01N33/74 , G01N2800/24 , G01N2800/52
摘要： The invention relates to materials and methods for regulating immune pathways using NOTCH and NOTCH agonists. In particular, said agonists may be used in methods for sensitizing CD4+ CD25- cells to CD4+ CD25+ cell-mediated immunosuppression, for enhancing the TGF-β response of CD4+ CD25- cells.
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7.发明公开
公开(公告)号：EP3402469A1
公开(公告)日：2018-11-21
申请号：EP17701075.8
申请日：2017-01-13
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Université Paris-Est Créteil Val de Marne , Assistance Publique-Hôpitaux de Paris (AP-HP)
CPC分类号： A61K31/00
摘要： The present invention relates to pharmaceutical composition and uses thereof for restoring T-cell lymphopoiesis in subjects infected with human immunodeficiency virus (HIV). In particular, the present invention relates to a P2X7 receptor antagonist for use in a method of restoring T-cell lymphopoiesis in a subject infected with human immunodeficiency virus (HIV) comprising administering to the subject a therapeutically effective amount of said P2X7 receptor antagonist.
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8.发明公开
公开(公告)号：EP4157343A2
公开(公告)日：2023-04-05
申请号：EP21728243.3
申请日：2021-05-26
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Baylor Research Institute , Assistance Publique-Hôpitaux de Paris (APHP) , Université Paris-Est Créteil Val de Marne
发明人： LEVY, Yves , ZURAWSKI, Gérard , ZURAWSKI, Sandra , LACABARATZ, Christine , CARDINAUD, Sylvain , SURENAUD, Mathieu
IPC分类号： A61K39/12 , A61K39/215 , A61P31/14 , C07K14/165
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公开(公告)号：EP4244253A1
公开(公告)日：2023-09-20
申请号：EP21806276.8
申请日：2021-11-10
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , Assistance Publique Hôpitaux de Paris , Baylor Research Institute , Université Paris-Est Créteil Val de Marne
IPC分类号： C07K16/28 , A61K39/215 , C07K14/165 , A61P31/14 , A61K39/12
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公开(公告)号：EP4433504A1
公开(公告)日：2024-09-25
申请号：EP22818329.9
申请日：2022-11-16
申请人： Institut National de la Santé et de la Recherche Médicale , Assistance Publique des Hopitaux de Paris , Baylor Research Institute , Université Paris Est Créteil Val de Marne
发明人： LEVY, Yves , ZURAWSKI, Gérard , ZURAWSKI, Sandra , CENTLIVRE, Mireille , LACABARATZ, Christine , CARDINAUD, Sylvain , SURENAUD, Mathieu
IPC分类号： C07K16/28 , C07K14/165 , A61K39/12
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