公开(公告)号：EP4276111A1

公开(公告)日：2023-11-15

申请号：EP22736575.6

申请日：2022-01-07

申请人： Beijing Hanmi Pharmaceutical Co., Ltd.

发明人： LIU, Yang ,  ZHANG, Ruijing ,  FAN, Fei ,  LI, Xiaochun ,  YU, Lu ,  LIU, Jiawang ,  LEE, Kyoung Woo

IPC分类号： C07K16/28 ,  A61P35/00 ,  A61K39/395 ,  C12N15/13

摘要： Provided are an antibody specifically binding to 4-1BB and an antigen-binding fragment thereof. The antibody specifically binding to 4-1BB and the antigen-binding fragment of the antibody have high specificity, and after being binded to an antigen, the antibody and the antigen-binding fragment thereof can enhance an immune killing function of T cells, can induce activation of immune cells and promote secretion of cytokines, and can significantly inhibit the growth of tumors in the body.