公开(公告)号：EP1722818A2

公开(公告)日：2006-11-22

申请号：EP05703240.1

申请日：2005-02-17

申请人： Ben Gurion University of the Negev Research and Development Authority Ltd.

发明人： SHOSHAN-BARMATZ, Varda ,  ISRAELSON, Adrian

IPC分类号： A61K47/00

CPC分类号： C07K14/4728 ,  A61K38/00 ,  A61K41/0042 ,  A61K51/02 ,  G01N2333/4727

摘要： The present invention provides a photoreactive reagent that binds specifically to Ca2+-binding proteins, links to them covalently after photo-activation, and labels them. The novel reagent enables the characterization, purification, inhibition and screening of Ca2+-binding proteins, as well as the preparation of a new affinity chromatography matrix and a new protein biosensor. The invention also relates to the use of the reagent in inhibiting apoptosis and necrosis and in diagnosing a disorder associated with a defect in the function of a Ca2+-binding protein, and in the preparation of a medicament for treating such disorders.