Systems and methods for preparing autologous fibrin glue
    3.
    发明公开
    Systems and methods for preparing autologous fibrin glue 有权
    Systeme und Verfahren zur Herstellung von autologem Fibrinklebstoff

    公开(公告)号:EP2204195A1

    公开(公告)日:2010-07-07

    申请号:EP10003009.7

    申请日:2003-01-15

    IPC分类号: A61L24/10

    摘要: The invention provides a system for preparing an autologous solid-fibrin web suitable for regenerating tissue in a living organism. The system includes a sealed primary container containing a separation medium and a low-density high-viscosity liquid. The separation medium is capable of separating red blood cells from plasma when the container contains blood and is centrifuged, and the primary container has a first pressure. The system further includes a sealed secondary container containing a calcium-coagulation activator. The secondary container has a second pressure that is less than the first pressure. The system also comprises a transfer device including a cannula having a first end and a second end. The first and second ends are capable of puncturing the sealed primary and secondary containers in order to provide fluid communication between the first and second containers. The low-density high-viscosity liquid of the primary container is capable of blocking flow through the cannula upon entering therein.

    摘要翻译: 本发明提供了一种用于制备适于再生生物体中的组织的自体固体纤维蛋白网的系统。 该系统包括含有分离介质和低密度高粘度液体的密封的初级容器。 当容器含有血液并离心时,分离介质能够将红细胞与血浆分离,并且主容器具有第一压力。 该系统还包括含有钙凝固活化剂的密封次级容器。 次级容器具有小于第一压力的第二压力。 所述系统还包括具有第一端和第二端的插管的转移装置。 第一和第二端能够刺穿密封的初级和次级容器,以便在第一和第二容器之间提供流体连通。 主要容器的低密度高粘度液体能够在进入其中时阻止穿过套管的流动。

    Systems and methods for preparing autologous fibrin glue
    5.
    发明公开
    Systems and methods for preparing autologous fibrin glue 有权
    Systeme und Verfahren zur Herstellung von autologen Fibrinkleber

    公开(公告)号:EP1772159A3

    公开(公告)日:2008-01-09

    申请号:EP06027028.7

    申请日:2003-01-15

    IPC分类号: A61L24/10

    摘要: The invention provides a system for preparing an autologous solid-fibrin web suitable for regenerating tissue in a living organism. The system includes a sealed primary container containing a separation medium and a low-density high-viscosity liquid. The separation medium is capable of separating red blood cells from plasma when the container contains blood and is centrifuged, and the primary container has a first pressure. The system further includes a sealed secondary container containing a calcium-coagulation activator. The secondary container has a second pressure that is less than the first pressure. The system also comprises a transfer device including a cannula having a first end and a second end. The first and second ends are capable of puncturing the sealed primary and secondary containers in order to provide fluid communication between the first and second containers. The low-density high-viscosity liquid of the primary container is capable of blocking flow through the cannula upon entering therein.

    摘要翻译: 本发明提供了一种用于制备适于再生生物体中的组织的自体固体纤维蛋白网的系统。 该系统包括含有分离介质和低密度高粘度液体的密封的初级容器。 当容器含有血液并离心时,分离介质能够将红细胞与血浆分离,并且主容器具有第一压力。 该系统还包括含有钙凝固活化剂的密封次级容器。 次级容器具有小于第一压力的第二压力。 所述系统还包括具有第一端和第二端的插管的转移装置。 第一和第二端能够刺穿密封的初级和次级容器,以便在第一和第二容器之间提供流体连通。 主要容器的低密度高粘度液体能够在进入其中时阻止穿过套管的流动。

    Systems and methods for preparing autologous fibrin glue
    6.
    发明公开
    Systems and methods for preparing autologous fibrin glue 有权
    一种制备自体纤维蛋白封闭剂工艺

    公开(公告)号:EP1772159A2

    公开(公告)日:2007-04-11

    申请号:EP06027028.7

    申请日:2003-01-15

    IPC分类号: A61L24/10

    摘要: The invention provides a system for preparing an autologous solid-fibrin web suitable for regenerating tissue in a living organism. The system includes a sealed primary container containing a separation medium and a low-density high-viscosity liquid. The separation medium is capable of separating red blood cells from plasma when the container contains blood and is centrifuged, and the primary container has a first pressure. The system further includes a sealed secondary container containing a calcium-coagulation activator. The secondary container has a second pressure that is less than the first pressure. The system also comprises a transfer device including a cannula having a first end and a second end. The first and second ends are capable of puncturing the sealed primary and secondary containers in order to provide fluid communication between the first and second containers. The low-density high-viscosity liquid of the primary container is capable of blocking flow through the cannula upon entering therein.

    Method for preparing a solid-fibrin web
    7.
    发明公开
    Method for preparing a solid-fibrin web 审中-公开
    方法zur Herstellung eines festen Fibrin-Netzes

    公开(公告)号:EP2305278A1

    公开(公告)日:2011-04-06

    申请号:EP10011683.9

    申请日:2003-06-26

    IPC分类号: A61K35/16

    CPC分类号: A61L24/106 A61K38/36

    摘要: The present invention relates to a method of preparing a solid-fibrin web or autologous fibrin glue by contacting plasma from a patient with a calcium-coagulation activator, and concurrently coagulating and axially centrifugating the plasma to form the solid-fibrin web, said web being suitable for regenerating body tissue in a living organism.

    摘要翻译: 本发明涉及一种通过使来自患者的血浆与钙凝固活化剂接触来制备固体纤维蛋白网或自体纤维蛋白胶的方法,并且同时凝结并轴向离心血浆以形成固体纤维蛋白网,所述纤维网是 适用于生物体内再生的身体组织。

    SYSTEMS AND METHODS FOR PREPARING AUTOLOGOUS FIBRIN GLUE
    9.
    发明授权
    SYSTEMS AND METHODS FOR PREPARING AUTOLOGOUS FIBRIN GLUE 有权
    圣彼得堡VERFAHREN ZUR HERSTELLUNG VON AUTOLOGEM FIBRINKLEBER

    公开(公告)号:EP1465675B1

    公开(公告)日:2007-03-21

    申请号:EP03703826.2

    申请日:2003-01-15

    IPC分类号: A61L24/10

    摘要: The invention provides a system for preparing an autologous solid-fibrin web suitable for regenerating tissue in a living organism. The system includes a sealed primary container containing a separation medium and a low-density high-viscosity liquid. The separation medium is capable of separating red blood cells from plasma when the container contains blood and is centrifuged, and the primary container has a first pressure. The system further includes a sealed secondary container containing a calcium-coagulation activator. The secondary container has a second pressure that is less than the first pressure. The system also comprises a transfer device including a cannula having a first end and a second end. The first and second ends are capable of puncturing the sealed primary and secondary containers in order to provide fluid communication between the first and second containers. The low-density high-viscosity liquid of the primary container is capable of blocking flow through the cannula upon entering therein.

    摘要翻译: 本发明提供了一种用于制备适于再生生物体中的组织的自体固体纤维蛋白网的系统。 该系统包括含有分离介质和低密度高粘度液体的密封的初级容器。 当容器含有血液并离心时,分离介质能够将红细胞与血浆分离,并且主容器具有第一压力。 该系统还包括含有钙凝固活化剂的密封次级容器。 次级容器具有小于第一压力的第二压力。 所述系统还包括具有第一端和第二端的插管的转移装置。 第一和第二端能够刺穿密封的初级和次级容器,以便在第一和第二容器之间提供流体连通。 主要容器的低密度高粘度液体能够在进入其中时阻止穿过套管的流动。

    SYSTEMS AND METHODS FOR PREPARING AUTOLOGOUS FIBRIN GLUE
    10.
    发明公开
    SYSTEMS AND METHODS FOR PREPARING AUTOLOGOUS FIBRIN GLUE 有权
    系统及其制造方法自体纤维蛋白胶

    公开(公告)号:EP1465675A2

    公开(公告)日:2004-10-13

    申请号:EP03703826.2

    申请日:2003-01-15

    IPC分类号: A61L24/10

    摘要: The invention provides a system for preparing an autologous solid-fibrin web suitable for regenerating tissue in a living organism. The system includes a sealed primary container containing a separation medium and a low-density high-viscosity liquid. The separation medium is capable of separating red blood cells from plasma when the container contains blood and is centrifuged, and the primary container has a first pressure. The system further includes a sealed secondary container containing a calcium-coagulation activator. The secondary container has a second pressure that is less than the first pressure. The system also comprises a transfer device including a cannula having a first end and a second end. The first and second ends are capable of puncturing the sealed primary and secondary containers in order to provide fluid communication between the first and second containers. The low-density high-viscosity liquid of the primary container is capable of blocking flow through the cannula upon entering therein.