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    MICROFLUIDIC DEVICES HAVING ISOLATION PENS AND METHODS OF TESTING BIOLOGICAL MICRO-OBJECTS WITH SAME
    1.
    发明公开
    MICROFLUIDIC DEVICES HAVING ISOLATION PENS AND METHODS OF TESTING BIOLOGICAL MICRO-OBJECTS WITH SAME 审中-公开
    用绝缘引脚和方法生物微物体测试微流体装置THAT

    公开(公告)号：EP3060645A1

    公开(公告)日：2016-08-31

    申请号：EP14855668.1

    申请日：2014-10-22

    申请人： Berkeley Lights, Inc.

    发明人： HOBBS, Eric D. ,  WHITE, Mark P. ,  NEVILL, J. Tanner ,  MALLEO, Daniele ,  SHORT, Steven W.

    IPC分类号： C12M1/24 ,  C12M1/34 ,  G01N35/08

    CPC分类号： B01L3/502761 ,  B01L2200/0647 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0424 ,  B01L2400/0433 ,  B01L2400/0454 ,  G01N33/558 ,  G01N2469/20

    摘要： A microfluidic device can comprise at least one swept region that is fluidically connected to unswept regions. The fluidic connections between the swept region and the unswept regions can enable diffusion but substantially no flow of media between the swept region and the unswept regions. The capability of biological micro-objects to produce an analyte of interest can be assayed in such a microfluidic device. Biological micro-objects in sample material loaded into a microfluidic device can be selected for particular characteristics and disposed into unswept regions. The sample material can then be flowed out of the swept region and an assay material flowed into the swept region. Flows of medium in the swept region do not substantially affect the biological micro-objects in the unswept regions, but any analyte of interest produced by a biological micro-object can diffuse from an unswept region into the swept region, where the analyte can react with the assay material to produce a localized detectable reaction. Any such detected reactions can be analyzed to determine which, if any, of the biological micro-objects are producers of the analyte of interest.

    摘要翻译： 一种微流体装置可包括至少一个扫掠区并流体地连接到未波及区域。 扫掠区和未波及区域之间的流体连接可以使扩散，但基本上扫掠区域和未波及区域之间没有的媒体流。 生物微对象的，以产生所关注的分析物的能力，可以在寻求的微流体装置来测定。 在加载到微流体装置的样品材料的生物微对象可以被选择用于特定的特性和设置成未波及区域。 然后将样品材料可以流出该区域和扫到测试材料流入掠区域。 在扫掠区域介质的流动基本上不影响在未波及区域的生物微对象，而是由一个生物微对象产生任何感兴趣的分析物可以从在未波及区域扩散到扫掠区，其中该分析物可与测定反应 材料以产生局部检测的反应。 任何调查检测反应可以进行分析，以确定我的，如果有的话，生物微对象感兴趣的分析物的生产。

    MICROFLUIDIC DEVICES HAVING ISOLATION PENS AND METHODS OF TESTING BIOLOGICAL MICRO-OBJECTS WITH SAME
    2.
    发明公开
    MICROFLUIDIC DEVICES HAVING ISOLATION PENS AND METHODS OF TESTING BIOLOGICAL MICRO-OBJECTS WITH SAME 审中-公开

    公开(公告)号：EP3473700A1

    公开(公告)日：2019-04-24

    申请号：EP18205544.2

    申请日：2014-10-22

    申请人： Berkeley Lights, Inc.

    发明人： HOBBS, Eric D. ,  WHITE, Mark P. ,  NEVILL, J. Tanner ,  MALLEO, Daniele ,  SHORT, Steven W.

    IPC分类号： C12M1/24 ,  C12M1/34 ,  G01N35/08

    摘要： A microfluidic device can comprise at least one swept region that is fluidically connected to unswept regions. The fluidic connections between the swept region and the unswept regions can enable diffusion but substantially no flow of media between the swept region and the unswept regions. The capability of biological micro-objects to produce an analyte of interest can be assayed in such a microfluidic device. Biological micro-objects in sample material loaded into a microfluidic device can be selected for particular characteristics and disposed into unswept regions. The sample material can then be flowed out of the swept region and an assay material flowed into the swept region. Flows of medium in the swept region do not substantially affect the biological micro-objects in the unswept regions, but any analyte of interest produced by a biological micro-object can diffuse from an unswept region into the swept region, where the analyte can react with the assay material to produce a localized detectable reaction. Any such detected reactions can be analyzed to determine which, if any, of the biological micro-objects are producers of the analyte of interest.

    MICROFLUIDIC DEVICES HAVING ISOLATION PENS AND METHODS OF TESTING BIOLOGICAL MICRO-OBJECTS WITH SAME
    5.
    发明公开
    MICROFLUIDIC DEVICES HAVING ISOLATION PENS AND METHODS OF TESTING BIOLOGICAL MICRO-OBJECTS WITH SAME 审中-公开

    公开(公告)号：EP3760703A1

    公开(公告)日：2021-01-06

    申请号：EP20174036.2

    申请日：2014-10-22

    申请人： Berkeley Lights, Inc.

    发明人： HOBBS, Eric D. ,  WHITE, Mark P. ,  NEVILL J., Tanner ,  MALLEO, Daniele ,  SHORT, Steven W.

    IPC分类号： C12M1/24 ,  C12M1/34 ,  G01N35/08

    摘要： A microfluidic device can comprise at least one swept region that is fluidically connected to unswept regions. The fluidic connections between the swept region and the unswept regions can enable diffusion but substantially no flow of media between the swept region and the unswept regions. The capability of biological micro-objects to produce an analyte of interest can be assayed in such a microfluidic device. Biological micro-objects in sample material loaded into a microfluidic device can be selected for particular characteristics and disposed into unswept regions. The sample material can then be flowed out of the swept region and an assay material flowed into the swept region. Flows of medium in the swept region do not substantially affect the biological micro-objects in the unswept regions, but any analyte of interest produced by a biological micro-object can diffuse from an unswept region into the swept region, where the analyte can react with the assay material to produce a localized detectable reaction. Any such detected reactions can be analyzed to determine which, if any, of the biological micro-objects are producers of the analyte of interest.