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1.发明公开5- [4- (4- (2 -AMINO- 2 -METHOXYCARBONYLETHYL) PHENOXY) BENZILIDENE]THIAZOLIDIN-2 , 4-DION E DERIVATIVES AND RELATED COMPOUNDS FOR REDUCING GLUCOSE, CHOLESTEROL AND TRIGLYCERIDE LEVELS IN PLASMA 有权的盐（S）-2-氨基-3- {4- [4-（2,4-二氧代噻唑-5-基甲基）苯氧基]苯基} - 丙酸甲酯及其ALS白细胞介素抑制剂用于治疗肥胖症，OR 糖尿病
公开(公告)号：EP1848700A1
公开(公告)日：2007-10-31
申请号：EP06735487.8
申请日：2006-02-17
发明人： NAG, Bishwajit , NAG, Abhijeet , DEY, Debendranath , AGARWAL, Shiv Kumar , NEOGI, Partha , REDDY, Gaddam Om , BADIGER, Sangamesh , SINGH, Gajendra , PANDEY, Surendra Kumar , CHITHRA, Santhanagopalan
IPC分类号： C07D277/20 , C07D277/34 , C07D277/36 , A61P3/10
CPC分类号： C07D277/20 , A61K31/4164 , A61K31/421 , A61K31/426 , C07D277/34 , C07D277/36
摘要： Diphenyl ether compounds of the formula (I) are provided th-it exhibit activity useful for reducing glucose, cholesterol, and/or triglyceride levels in plasma, and for treatment of obesity, inflammation, immunological diseases, autoimmune diseases, diabetes and disorders associated with insulin resistance. (I) wherein represents an optional bond; W represents O or S; Z represents CR10, O or S; G represents O, S or together with R10 forms a 5 or 6 membered aromatic or heteroaromatic ring system containing 1 or 2 heteroatoms selected from the group consisting of O, S and N; R8 represents OR13 or NR14R15; where R13 is selected from the group consisting of hydrogen, substituted and unsubstituted (C1-C20) alkyl, (C2-C20) alkenyl, (C5-C14) aryl, (C6-C34) aralkyl, (C1C13) heteroaryl, and a counter ion; and where R14 and R15 are independently selected from the group consisting of H, substituted and unsubstituted (C1-C20) alkyl, (C2-C20) alkenyl and (C5-C14) aryl; the other substituents are defined in the claims.
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2.发明授权SALTS OF (S)-2-AMINO-3-{4-[4-(2,4-DIOXO-THIAZOLIDIN-5-YLMETHYL)-PHENOXY]-PHENYL}-PROPIONIC ACID AND ITS METHYL ESTER AS INTERLEUKIN INHIBITORS FOR THE TREATMENT OF OBESITY OR DIABETES 有权的盐（S）-2-氨基-3- {4- [4-（2,4-二氧代噻唑-5-基甲基）苯氧基]苯基} - 丙酸甲酯及其ALS白细胞介素抑制剂用于治疗肥胖症，OR 糖尿病
公开(公告)号：EP1848700B1
公开(公告)日：2015-12-30
申请号：EP06735487.8
申请日：2006-02-17
发明人： NAG, Bishwajit , NAG, Abhijeet , DEY, Debendranath , AGARWAL, Shiv Kumar , NEOGI, Partha , REDDY, Gaddam Om , BADIGER, Sangamesh , SINGH, Gajendra , PANDEY, Surendra Kumar , CHITHRA, Santhanagopalan
IPC分类号： C07D277/20 , C07D277/34 , C07D277/36 , A61P3/10
CPC分类号： C07D277/20 , A61K31/4164 , A61K31/421 , A61K31/426 , C07D277/34 , C07D277/36
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