CRYSTALLINE FORMS AND PROCESSES FOR THEIR PREPARATION
    2.
    发明公开
    CRYSTALLINE FORMS AND PROCESSES FOR THEIR PREPARATION 有权
    晶体形式和过程FOR THEIR

    公开(公告)号:EP2655363A2

    公开(公告)日:2013-10-30

    申请号:EP11811184.8

    申请日:2011-12-21

    IPC分类号: C07D405/04

    CPC分类号: C07D405/04

    摘要: The present invention relates to crystalline Form A of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione and crystalline Form B of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione, processes for preparing the forms and their uses in medicine. The present invention also relates to the amorphous form of 1-[(3R)-6,8-difluoro-3,4-dihydro-2H-1-benzopyran-3-yl]-1,3-dihydro-5-[2-[(phenylmethyl)amino]ethyl]-2H-imidazole-2-thione processes for preparing it and its uses in medicine.