公开(公告)号：EP2726454B1

公开(公告)日：2018-01-24

申请号：EP12738246.3

申请日：2012-06-29

申请人： Bial-Portela & CA, S.A.

发明人： BELIAEV, Alexander ,  WAHNON, Jorge Bruno Reis ,  LEARMONTH, David Alexander ,  MADEC, Jonathan ,  SCHNEIDER, Jean-Marie ,  MATON, William

IPC分类号： C07C311/19 ,  C07D403/04

CPC分类号： C07D405/04 ,  C07C235/80 ,  C07C311/16 ,  C07C311/17

摘要： The present invention relates to a process for preparing (R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1H-imidazole-2(3H)-thione, and pharmaceutically acceptable salts thereof, especially the hydrochloride salt. The invention also relates to a process for making intermediates useful in the formation of said compound, and to the intermediates, per se.

公开(公告)号：EP2726454A2

公开(公告)日：2014-05-07

申请号：EP12738246.3

申请日：2012-06-29

申请人： Bial-Portela & CA, S.A.

发明人： BELIAEV, Alexander ,  WAHNON, Jorge Bruno Reis ,  LEARMONTH, David Alexander ,  MADEC, Jonathan ,  SCHNEIDER, Jean-Marie ,  MATON, William

IPC分类号： C07C311/19 ,  C07D403/04

CPC分类号： C07D405/04 ,  C07C235/80 ,  C07C311/16 ,  C07C311/17

摘要： The present invention relates to a process for preparing (R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1H-imidazole-2(3H)-thione, and pharmaceutically acceptable salts thereof, especially the hydrochloride salt. The invention also relates to a process for making intermediates useful in the formation of said compound, and to the intermediates, per se.