专利检索 ap:("Bial-Portela & CA, S.A.") AND inv:"SOUSA, Luísa" 第 1 页

1.

发明公开
PROCESSES FOR PREPARING MEDICAMENTS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES AND INTERMEDIATES FOR USE THEREIN 审中-公开
标题翻译： PROCESS关于药品的心血管疾病及其使用中间产品制备治疗

公开(公告)号：EP3044215A1

公开(公告)日：2016-07-20

申请号：EP14772233.4

申请日：2014-09-12

申请人： Bial-Portela & CA, S.A.

发明人： RUSSO, Domenico , WAHNON, Jorge , MATON, William , WEBER, Beat T. , JERÓNIMO, Paula , SOUSA, Luísa , BARROCAS, Pedro , PIRES, Rita , LIMA, Ricardo , VASCONCELOS, Teófilo

IPC分类号： C07D311/12 , C07D311/20

CPC分类号： C07D311/58 , C07C51/41 , C07D311/12 , C07D311/20 , C07D405/04

摘要： The present invention provides a compound of formula N wherein: X is CH
2 , oxygen or sulphur; R
1 , R
2 and R
3 are the same or different and signify hydrogens, halogens, alkyl, alkyloxy, hydroxy, nitro, alkylcarbonylamino, alkylamino or dialkylamino group, wherein N is in the form of the individual R- and S-enantiomer or a mixture of the (R)- and (S)-enantiomer. The present invention also provides a compound of formula MA. The present invention also provides processes for preparing the above compounds, and processes involving their use. The compounds are particularly useful as intermediates in the synthesis of peripherally-selective inhibitors of dopamine-ß-hydroxylase.